利用生物发光分子进行脑深部成像是否即将实现变革?

BMEMat Pub Date : 2024-08-16 DOI:10.1002/bmm2.12115
Shumao Xu, Farid Manshaii, Jun Chen
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引用次数: 0

摘要

头孢呋嗪(Cephalofurimazine,CFz)与 Antares 荧光素酶配伍后,显示出卓越的血脑屏障渗透性,并增强了脑深部成像的成像深度和清晰度。这种生物发光技术为实时监测大脑深部活动提供了一种侵入性较小的方法,有望推动靶向治疗,加深我们对大脑功能的了解。进一步的分子工程和局部给药可以降低 CFz 的潜在毒性,提高其在临床脑深部成像中的功效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Is deep brain imaging on the brink of transformation with a bioluminescence molecule?

Cephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.

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