Hai-Peng Tang , En-Lin Zhu , Qian-Xiang Bai , Shuang Wang , Zhi-Bin Wang , Meng Wang , Hai-Xue Kuang
{"title":"日本远志关于其植物学、传统用途、植物化学、药理学和药代动力学的全面综述","authors":"Hai-Peng Tang , En-Lin Zhu , Qian-Xiang Bai , Shuang Wang , Zhi-Bin Wang , Meng Wang , Hai-Xue Kuang","doi":"10.1016/j.fitote.2024.106233","DOIUrl":null,"url":null,"abstract":"<div><div><em>Polygala japonica</em> Houtt. (<em>P. japonica</em>), a member of the <em>Polygala</em> genus in the <em>Polygalaceae</em> family, has been historically utilized in traditional folk medicine as an expectorant, anti-inflammatory, anti-bacterial, and anti-depressant agent. This paper systematically reviews the latest research in botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics, aiming to provide a scientific foundation for the future development and application of <em>P. japonica</em> and to explore its potential value comprehensively. Approximately 86 compounds have been isolated from <em>P. japonica</em>, with triterpenoid saponins being the most prevalent and bioactive components. Extensive pharmacological activities of <em>P. japonica</em> extracts or compounds have been confirmed <em>in vivo</em> and <em>in vitro</em>, including anti-inflammatory, anti-depressant, neuroprotective, anti-obesity, anti-apoptotic, and skin-protective effects. Additionally, <em>P. japonica</em> has demonstrated significant curative effects and relatively clear pharmacological mechanisms in treating inflammatory and nervous system diseases. Specific components of its primary triterpenoid saponins are rapidly absorbed in the body. This review advocates for deeper scientific research on <em>P. japonica</em>, noting that most current research remains in its early stages and many reported biological activities require further clinical validation. Despite this, the traditional medical use of <em>P. japonica</em> across various cultures attests to its broad application value. Presently, the pharmacological activities of <em>P. japonica</em> extracts and compounds provide a scientific basis for its traditional uses. Future research must ensure the safety and effectiveness of <em>P. japonica</em> through in-depth pharmacokinetic studies, and the establishment of a refined and standardized quality evaluation system is essential for its clinical development and application.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polygala japonica Houtt.: A comprehensive review on its botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics\",\"authors\":\"Hai-Peng Tang , En-Lin Zhu , Qian-Xiang Bai , Shuang Wang , Zhi-Bin Wang , Meng Wang , Hai-Xue Kuang\",\"doi\":\"10.1016/j.fitote.2024.106233\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Polygala japonica</em> Houtt. (<em>P. japonica</em>), a member of the <em>Polygala</em> genus in the <em>Polygalaceae</em> family, has been historically utilized in traditional folk medicine as an expectorant, anti-inflammatory, anti-bacterial, and anti-depressant agent. This paper systematically reviews the latest research in botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics, aiming to provide a scientific foundation for the future development and application of <em>P. japonica</em> and to explore its potential value comprehensively. Approximately 86 compounds have been isolated from <em>P. japonica</em>, with triterpenoid saponins being the most prevalent and bioactive components. Extensive pharmacological activities of <em>P. japonica</em> extracts or compounds have been confirmed <em>in vivo</em> and <em>in vitro</em>, including anti-inflammatory, anti-depressant, neuroprotective, anti-obesity, anti-apoptotic, and skin-protective effects. Additionally, <em>P. japonica</em> has demonstrated significant curative effects and relatively clear pharmacological mechanisms in treating inflammatory and nervous system diseases. Specific components of its primary triterpenoid saponins are rapidly absorbed in the body. This review advocates for deeper scientific research on <em>P. japonica</em>, noting that most current research remains in its early stages and many reported biological activities require further clinical validation. Despite this, the traditional medical use of <em>P. japonica</em> across various cultures attests to its broad application value. Presently, the pharmacological activities of <em>P. japonica</em> extracts and compounds provide a scientific basis for its traditional uses. Future research must ensure the safety and effectiveness of <em>P. japonica</em> through in-depth pharmacokinetic studies, and the establishment of a refined and standardized quality evaluation system is essential for its clinical development and application.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004167\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004167","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Polygala japonica Houtt.: A comprehensive review on its botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics
Polygala japonica Houtt. (P. japonica), a member of the Polygala genus in the Polygalaceae family, has been historically utilized in traditional folk medicine as an expectorant, anti-inflammatory, anti-bacterial, and anti-depressant agent. This paper systematically reviews the latest research in botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics, aiming to provide a scientific foundation for the future development and application of P. japonica and to explore its potential value comprehensively. Approximately 86 compounds have been isolated from P. japonica, with triterpenoid saponins being the most prevalent and bioactive components. Extensive pharmacological activities of P. japonica extracts or compounds have been confirmed in vivo and in vitro, including anti-inflammatory, anti-depressant, neuroprotective, anti-obesity, anti-apoptotic, and skin-protective effects. Additionally, P. japonica has demonstrated significant curative effects and relatively clear pharmacological mechanisms in treating inflammatory and nervous system diseases. Specific components of its primary triterpenoid saponins are rapidly absorbed in the body. This review advocates for deeper scientific research on P. japonica, noting that most current research remains in its early stages and many reported biological activities require further clinical validation. Despite this, the traditional medical use of P. japonica across various cultures attests to its broad application value. Presently, the pharmacological activities of P. japonica extracts and compounds provide a scientific basis for its traditional uses. Future research must ensure the safety and effectiveness of P. japonica through in-depth pharmacokinetic studies, and the establishment of a refined and standardized quality evaluation system is essential for its clinical development and application.
期刊介绍:
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.