日本远志关于其植物学、传统用途、植物化学、药理学和药代动力学的全面综述

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-09-24 DOI:10.1016/j.fitote.2024.106233
Hai-Peng Tang , En-Lin Zhu , Qian-Xiang Bai , Shuang Wang , Zhi-Bin Wang , Meng Wang , Hai-Xue Kuang
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引用次数: 0

摘要

远志(Polygala japonica Houtt.(远志(P. japonica)是远志科远志属植物,在传统民间医药中一直被用作祛痰、消炎、抗菌和抗抑郁药物。本文系统地综述了植物学、传统用途、植物化学、药理学和药代动力学等方面的最新研究成果,旨在为日后的开发和应用提供科学依据,并全面发掘其潜在价值。目前已从白花蛇舌草中分离出约 86 种化合物,其中三萜类皂苷是最常见的生物活性成分。已在体内和体外证实了 P. japonica 提取物或化合物的广泛药理活性,包括抗炎、抗抑郁、神经保护、抗肥胖、抗细胞凋亡和皮肤保护作用。此外,P. japonica 在治疗炎症和神经系统疾病方面具有显著疗效和相对明确的药理机制。其主要三萜类皂苷的特定成分可被人体快速吸收。这篇综述提倡对白花蛇舌草进行更深入的科学研究,并指出目前的大多数研究仍处于早期阶段,许多已报道的生物活性还需要进一步的临床验证。尽管如此,不同文化背景下的传统医学使用证明了白花蛇舌草的广泛应用价值。目前,P. japonica 提取物和化合物的药理活性为其传统用途提供了科学依据。未来的研究必须通过深入的药代动力学研究来确保白花蛇舌草的安全性和有效性,而建立完善和标准化的质量评价体系对于白花蛇舌草的临床开发和应用至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Polygala japonica Houtt.: A comprehensive review on its botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics
Polygala japonica Houtt. (P. japonica), a member of the Polygala genus in the Polygalaceae family, has been historically utilized in traditional folk medicine as an expectorant, anti-inflammatory, anti-bacterial, and anti-depressant agent. This paper systematically reviews the latest research in botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics, aiming to provide a scientific foundation for the future development and application of P. japonica and to explore its potential value comprehensively. Approximately 86 compounds have been isolated from P. japonica, with triterpenoid saponins being the most prevalent and bioactive components. Extensive pharmacological activities of P. japonica extracts or compounds have been confirmed in vivo and in vitro, including anti-inflammatory, anti-depressant, neuroprotective, anti-obesity, anti-apoptotic, and skin-protective effects. Additionally, P. japonica has demonstrated significant curative effects and relatively clear pharmacological mechanisms in treating inflammatory and nervous system diseases. Specific components of its primary triterpenoid saponins are rapidly absorbed in the body. This review advocates for deeper scientific research on P. japonica, noting that most current research remains in its early stages and many reported biological activities require further clinical validation. Despite this, the traditional medical use of P. japonica across various cultures attests to its broad application value. Presently, the pharmacological activities of P. japonica extracts and compounds provide a scientific basis for its traditional uses. Future research must ensure the safety and effectiveness of P. japonica through in-depth pharmacokinetic studies, and the establishment of a refined and standardized quality evaluation system is essential for its clinical development and application.
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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