{"title":"空间致密肾上腺素能刺激对模拟心房片转子行为的影响","authors":"","doi":"10.1016/j.compbiomed.2024.109195","DOIUrl":null,"url":null,"abstract":"<div><div>Sympathetic hyperactivity via spatially dense adrenergic stimulation may create pro-arrhythmic substrates even without structural remodelling. However, the effect of sympathetic hyperactivity on arrhythmic activity, such as rotors, is unknown. Using simulations, we examined the effects of gradually increasing the spatial density of adrenergic stimulation (AS) in atrial sheets on rotors. We compared their characteristics against rotors hosted in atrial sheets with increasing spatial density of minimally conductive (MC) elements to simulate structural remodelling due to injury or disease. We generated rotors using an S1-S2 stimulation protocol. Then, we created phase maps to identify phase singularities and map their trajectory over time. We measured each rotor’s duration (s), angular speed (rad/s), and spatiotemporal organization. We demonstrated that atrial sheets with increased AS spatial densities could maintain rotors longer than with MC elements (2.6 ± 0.1 s vs. 1.5 ± 0.2 s, <span><math><mrow><mi>p</mi><mo><</mo><mn>0</mn><mo>.</mo><mn>001</mn></mrow></math></span>). Moreover, rotors have higher angular speed (70 ± 7 rads/s vs. 60 ± 15 rads/s, <span><math><mrow><mi>p</mi><mo><</mo><mn>0</mn><mo>.</mo><mn>05</mn></mrow></math></span>) and better spatiotemporal organization (0.56 ± 0.05 vs. 0.58 ± 0.18, <span><math><mrow><mi>p</mi><mo><</mo><mn>0</mn><mo>.</mo><mn>05</mn></mrow></math></span>) in atrial sheets with less than 25% AS elements compared to MC elements. Our findings may help elucidate electrophysiological potential alterations in atrial substrates due to sympathetic hyperactivity, particularly among individuals with autonomic derangements caused by chronic distress.</div></div>","PeriodicalId":10578,"journal":{"name":"Computers in biology and medicine","volume":null,"pages":null},"PeriodicalIF":7.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of spatially dense adrenergic stimulation to rotor behaviour in simulated atrial sheets\",\"authors\":\"\",\"doi\":\"10.1016/j.compbiomed.2024.109195\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Sympathetic hyperactivity via spatially dense adrenergic stimulation may create pro-arrhythmic substrates even without structural remodelling. However, the effect of sympathetic hyperactivity on arrhythmic activity, such as rotors, is unknown. Using simulations, we examined the effects of gradually increasing the spatial density of adrenergic stimulation (AS) in atrial sheets on rotors. We compared their characteristics against rotors hosted in atrial sheets with increasing spatial density of minimally conductive (MC) elements to simulate structural remodelling due to injury or disease. We generated rotors using an S1-S2 stimulation protocol. Then, we created phase maps to identify phase singularities and map their trajectory over time. We measured each rotor’s duration (s), angular speed (rad/s), and spatiotemporal organization. We demonstrated that atrial sheets with increased AS spatial densities could maintain rotors longer than with MC elements (2.6 ± 0.1 s vs. 1.5 ± 0.2 s, <span><math><mrow><mi>p</mi><mo><</mo><mn>0</mn><mo>.</mo><mn>001</mn></mrow></math></span>). Moreover, rotors have higher angular speed (70 ± 7 rads/s vs. 60 ± 15 rads/s, <span><math><mrow><mi>p</mi><mo><</mo><mn>0</mn><mo>.</mo><mn>05</mn></mrow></math></span>) and better spatiotemporal organization (0.56 ± 0.05 vs. 0.58 ± 0.18, <span><math><mrow><mi>p</mi><mo><</mo><mn>0</mn><mo>.</mo><mn>05</mn></mrow></math></span>) in atrial sheets with less than 25% AS elements compared to MC elements. Our findings may help elucidate electrophysiological potential alterations in atrial substrates due to sympathetic hyperactivity, particularly among individuals with autonomic derangements caused by chronic distress.</div></div>\",\"PeriodicalId\":10578,\"journal\":{\"name\":\"Computers in biology and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computers in biology and medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010482524012800\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computers in biology and medicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010482524012800","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
即使没有结构重塑,通过空间致密肾上腺素能刺激产生的交感神经亢进也可能创造出有利于心律失常的基质。然而,交感神经过度活跃对转子等心律失常活动的影响尚不清楚。通过模拟,我们研究了逐渐增加心房片中肾上腺素能刺激(AS)的空间密度对转子的影响。我们将转子的特性与心房片中不断增加的微传导(MC)元件空间密度寄存的转子进行了比较,以模拟因损伤或疾病导致的结构重塑。我们使用 S1-S2 刺激方案生成转子。然后,我们绘制了相位图,以识别相位奇异点并绘制其随时间变化的轨迹。我们测量了每个转子的持续时间(秒)、角速度(拉德/秒)和时空组织。我们发现,与 MC 元素相比,AS 空间密度增加的心房片可维持转子的时间更长(2.6 ± 0.1 秒 vs. 1.5 ± 0.2 秒,p<0.001)。此外,与 MC 元素相比,在 AS 元素少于 25% 的心房片中,转子具有更高的角速度(70 ± 7 rads/s vs. 60 ± 15 rads/s,p<0.05)和更好的时空组织(0.56 ± 0.05 vs. 0.58 ± 0.18,p<0.05)。我们的研究结果可能有助于阐明交感神经亢进导致的心房基底电生理潜在改变,尤其是在因长期窘迫导致自律神经失调的人群中。
Effects of spatially dense adrenergic stimulation to rotor behaviour in simulated atrial sheets
Sympathetic hyperactivity via spatially dense adrenergic stimulation may create pro-arrhythmic substrates even without structural remodelling. However, the effect of sympathetic hyperactivity on arrhythmic activity, such as rotors, is unknown. Using simulations, we examined the effects of gradually increasing the spatial density of adrenergic stimulation (AS) in atrial sheets on rotors. We compared their characteristics against rotors hosted in atrial sheets with increasing spatial density of minimally conductive (MC) elements to simulate structural remodelling due to injury or disease. We generated rotors using an S1-S2 stimulation protocol. Then, we created phase maps to identify phase singularities and map their trajectory over time. We measured each rotor’s duration (s), angular speed (rad/s), and spatiotemporal organization. We demonstrated that atrial sheets with increased AS spatial densities could maintain rotors longer than with MC elements (2.6 ± 0.1 s vs. 1.5 ± 0.2 s, ). Moreover, rotors have higher angular speed (70 ± 7 rads/s vs. 60 ± 15 rads/s, ) and better spatiotemporal organization (0.56 ± 0.05 vs. 0.58 ± 0.18, ) in atrial sheets with less than 25% AS elements compared to MC elements. Our findings may help elucidate electrophysiological potential alterations in atrial substrates due to sympathetic hyperactivity, particularly among individuals with autonomic derangements caused by chronic distress.
期刊介绍:
Computers in Biology and Medicine is an international forum for sharing groundbreaking advancements in the use of computers in bioscience and medicine. This journal serves as a medium for communicating essential research, instruction, ideas, and information regarding the rapidly evolving field of computer applications in these domains. By encouraging the exchange of knowledge, we aim to facilitate progress and innovation in the utilization of computers in biology and medicine.