Yu-Meng Li, Yunseong Ji, Yu-Xuan Meng, Yu-Jin Kim, Hwalim Lee, Amal George Kurian, Jeong-Hui Park, Ji-Young Yoon, Jonathan C. Knowles, Yunkyu Choi, Yoon-Sik Kim, Bo-Eun Yoon, Rajendra K. Singh, Hae-Hyoung Lee, Hae-Won Kim, Jung-Hwan Lee
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引用次数: 0
摘要
依赖电导率的神经元分化在文章编号 2400586 中，Hae-Won Kim、Jung-Hwan Lee 及合作者展示了类似神经组织的低电导率（0.02-0.1 S m-1）可通过平衡钙信号传导和表观遗传变化促进神经元分化，而超生理的高电导率（3.2 S m-1）则会导致神经细胞凋亡。这项研究揭示了最佳电导率在组织工程和再生医学的神经接口设计中的关键作用。
Neural Tissue-Like, not Supraphysiological, Electrical Conductivity Stimulates Neuronal Lineage Specification through Calcium Signaling and Epigenetic Modification (Adv. Sci. 35/2024)
Conductivity-Dependent Neuronal Specification
In article number 2400586, Hae-Won Kim, Jung-Hwan Lee, and co-workers show that neural-tissue-like, low conductivity (0.02–0.1 S m–1) promotes neuronal differentiation via balanced calcium signaling and epigenetic changes, while supraphysiological, high conductivity (3.2 S m–1) causes apoptosis. This work reveals optimal conductivity's crucial role in neural interface design for tissue engineering and regenerative medicine.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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