作为可调滤波器的矩阵铅笔

IF 2 3区 化学 Q3 BIOCHEMICAL RESEARCH METHODS Journal of magnetic resonance Pub Date : 2024-09-23 DOI:10.1016/j.jmr.2024.107780
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引用次数: 0

摘要

尽管存在固有的灵敏度限制,但核磁共振(NMR)在探测分子结构和分子动力学等科学学科中发挥着不可或缺的作用。值得注意的是,虽然人们已经针对仪器和实验灵敏度的提高做出了大量努力,但通过信号分析提高灵敏度的工作却相对较少。在这一空白中,矩阵铅笔法(MPM)作为一种多功能算法应运而生,它具有可调滤波和相位功能。此前的大量研究已经证明,矩阵铅笔法是信号分析中的一种有效拟合工具。本文通过对噪声数据进行精确建模来研究 MPM 的功效,从而将含信息的信号从噪声中分离出来,扩大其在各种磁共振应用中的实用性。模拟数据用于证实 MPM 从噪声中识别和分离信号的能力。与基于傅立叶的标准滤波方法进行的比较分析,凸显了矩阵铅笔滤波器(MPF)在保持信号保真度而不引入混叠伪影方面的优越性能。随后,还探讨了各种实验数据,以证明矩阵铅笔滤波器在表征信号成分和校正相位失真方面的能力。总之,这些案例研究强调了 MPM 的滤波能力,预示着 MPM 将在广泛的 NMR 应用中用于提高分析灵敏度。
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The matrix pencil as a tunable filter
Despite inherent sensitivity constraints, nuclear magnetic resonance (NMR) plays an indispensable role in probing molecular structures and dynamics across scientific disciplines. Remarkably, while extensive efforts have targeted instrumental and experimental sensitivity improvements, comparatively little focus has been dedicated to sensitivity enhancement through signal analysis. Amidst this present gap, the matrix pencil method (MPM) has emerged as a versatile algorithm that offers tunable filtering and phasing capabilities. Extensive prior research has established the MPM as an adept fitting tool in signal analysis. Here, the efficacy of the MPM is investigated by precisely modeling noisy data to separate information-bearing signals from noise, thereby expanding its utility in various magnetic resonance applications. Simulated data is used to confirm the ability of the MPM to discern and separate signals from noise. Comparative analyses against standard Fourier-based filtering methods highlight the superior performance of the matrix pencil filter (MPF) in preserving signal fidelity without introducing aliasing artifacts. A variety of experimental data is then explored to demonstrate the proficiency of the MPF in characterizing signal components and correcting phase distortions. Collectively, these case studies underscore the filtering capacity of the MPM, portending its use for analytical sensitivity improvements in a wide range of NMR applications.
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来源期刊
CiteScore
3.80
自引率
13.60%
发文量
150
审稿时长
69 days
期刊介绍: The Journal of Magnetic Resonance presents original technical and scientific papers in all aspects of magnetic resonance, including nuclear magnetic resonance spectroscopy (NMR) of solids and liquids, electron spin/paramagnetic resonance (EPR), in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), nuclear quadrupole resonance (NQR) and magnetic resonance phenomena at nearly zero fields or in combination with optics. The Journal''s main aims include deepening the physical principles underlying all these spectroscopies, publishing significant theoretical and experimental results leading to spectral and spatial progress in these areas, and opening new MR-based applications in chemistry, biology and medicine. The Journal also seeks descriptions of novel apparatuses, new experimental protocols, and new procedures of data analysis and interpretation - including computational and quantum-mechanical methods - capable of advancing MR spectroscopy and imaging.
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