Yiran Xu MD , Jingli Gao MD , Jingdi Zhang MD , Shaopeng Liu MD , Peng Yang MD , Youxin Wang MD , Xiangfeng Lu MD , Dandan Zhao MD , Shouling Wu PhD , Yun Li PhD
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引用次数: 0
摘要
研究发现，在癌症人群和年轻成年人中，生活必需品 8（LE8）的高分与心血管疾病（CVD）风险的降低有关。方法主要分析包括 6814 名高尿酸血症患者。在二次分析中，从主要分析中选取了5418名参与者，以模拟2006年至2010年尿酸（UA）水平的变化轨迹。结果在主要分析中，随访 15.79 年，共发生 986 起心血管疾病事件。以三等分 1 为对照组，三等分 2 和三等分 3 的心血管疾病 HR 和 95 % CI 分别为 0.75(0.65,0.87) 和 0.56(0.47,0.66)。在二次分析中，低水平和中等水平的 UA 可降低心血管疾病风险的 HR 和 95 %CI 分别为 0.49(0.26,0.89) 和 0.56(0.41,0.76)，但在 UA 水平持续较高的人群中未发现这种关联。心血管疾病的风险在性别上存在差异。结论 HUA人群的心血管疾病风险随着LE8评分的升高而降低，尤其是中青年和女性。然而，值得注意的是，LE8 可能无法降低 UA 水平持续偏高的人群的心血管疾病风险。
Life's essential 8 and cardiovascular disease among patients with hyperuricemia: The Kailuan Cohort Study
Objectives
Studies have found that a high Life's Essential 8 (LE8) score is associated with a reduced risk of cardiovascular disease(CVD) in cancer populations and young adults. However, the association between LE8 and the risk of CVD in hyperuricemia (HUA) is not fully understood.
Methods
The main analysis included 6814 HUA participants. In a secondary analysis, 5,418 participants were selected from the main analysis to model the trajectory of uric acid (UA) levels from 2006 to 2010. Cox regression model was used to investigate the relationship between LE8 total score and cardiovascular disease risk in different populations.
Results
Follow-up of 15.79 years in the main analysis, 986 CVD events occurred. With tertile 1 as the control group, the HR and 95 % CI of CVD in tertile 2 and tertile 3 were 0.75(0.65,0.87) and 0.56(0.47,0.66). In the secondary analysis, the HR and 95 %CI of individuals with low and medium levels of UA reduced CVD were 0.49(0.26,0.89) and 0.56(0.41,0.76), respectively, but this association was not found in individuals with sustained high UA levels. The risk of CVD was different between the sexes. There are differences in cardiovascular disease risk among different age groups.
Conclusions
The risk of CVD in HUA population decreased with the increase of LE8 score, especially in young and middle-aged people and women. However, it is important to note that LE8 may not reduce the risk of CVD in individuals with sustained high UA levels.
期刊介绍：
Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.
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