Karina Janson , Nathalie E. Holz , Anna Kaiser , Pascal Aggensteiner , Sarah Baumeister , Daniel Brandeis , Tobias Banaschewski , Frauke Nees , IMAC-Mind Consortium
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This study specifically aimed to explore the influence of prenatal smoking exposure on brain activity and whether internalizing and externalizing symptoms are influenced by prenatal smoking exposure in a cohort of young adults.</div></div><div><h3>Methods</h3><div>Utilizing data from 176 participants (mean age <em>M</em> = 24.68, <em>SD</em> = 0.49) and their mothers enrolled in a longitudinal risk study (MARS), we employed Generalized Additive Mixed Models (GAMMs) to analyze electroencephalography (EEG) power at rest and behavioral outcomes derived from the Young Adult-Self-Report (YASR) scales. Both covariate-unadjusted and −adjusted models were used, taking into account participant variables such as sex and age, as well as maternal factors like psychopathology and alcohol consumption, in addition to smoking and alcohol intake by the participants themselves.</div></div><div><h3>Results</h3><div>The study revealed a significant impact of prenatal smoking on delta and theta band power, indicating decreased slower brain activity in prenatally exposed individuals compared to unexposed counterparts. Additionally, individuals exposed to prenatal smoking exhibited significantly higher levels of externalizing behavior. While this association was strongly influenced by maternal psychopathology, the child’s gender, and the child’s own substance use, the effect on delta power band remained after adjusting for covariates.</div></div><div><h3>Conclusion</h3><div>The findings suggest that prenatal smoking exposure may have enduring effects on brain activity patterns in young adulthood. Conversely, the influence on externalizing behaviors depended on familial factors (maternal psychopathology) and the lifestyle of the individual (substance use).</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"160 ","pages":"Article 108175"},"PeriodicalIF":3.7000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term impact of maternal prenatal smoking on EEG brain activity and internalizing/externalizing problem symptoms in young adults\",\"authors\":\"Karina Janson , Nathalie E. Holz , Anna Kaiser , Pascal Aggensteiner , Sarah Baumeister , Daniel Brandeis , Tobias Banaschewski , Frauke Nees , IMAC-Mind Consortium\",\"doi\":\"10.1016/j.addbeh.2024.108175\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>The objective of this study was to investigate the impact of smoking during pregnancy on the development of the child. While previous research has established its detrimental effects during early childhood, understanding potential long-term consequences into adulthood remains limited. This study specifically aimed to explore the influence of prenatal smoking exposure on brain activity and whether internalizing and externalizing symptoms are influenced by prenatal smoking exposure in a cohort of young adults.</div></div><div><h3>Methods</h3><div>Utilizing data from 176 participants (mean age <em>M</em> = 24.68, <em>SD</em> = 0.49) and their mothers enrolled in a longitudinal risk study (MARS), we employed Generalized Additive Mixed Models (GAMMs) to analyze electroencephalography (EEG) power at rest and behavioral outcomes derived from the Young Adult-Self-Report (YASR) scales. Both covariate-unadjusted and −adjusted models were used, taking into account participant variables such as sex and age, as well as maternal factors like psychopathology and alcohol consumption, in addition to smoking and alcohol intake by the participants themselves.</div></div><div><h3>Results</h3><div>The study revealed a significant impact of prenatal smoking on delta and theta band power, indicating decreased slower brain activity in prenatally exposed individuals compared to unexposed counterparts. Additionally, individuals exposed to prenatal smoking exhibited significantly higher levels of externalizing behavior. While this association was strongly influenced by maternal psychopathology, the child’s gender, and the child’s own substance use, the effect on delta power band remained after adjusting for covariates.</div></div><div><h3>Conclusion</h3><div>The findings suggest that prenatal smoking exposure may have enduring effects on brain activity patterns in young adulthood. Conversely, the influence on externalizing behaviors depended on familial factors (maternal psychopathology) and the lifestyle of the individual (substance use).</div></div>\",\"PeriodicalId\":7155,\"journal\":{\"name\":\"Addictive behaviors\",\"volume\":\"160 \",\"pages\":\"Article 108175\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Addictive behaviors\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306460324002247\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, CLINICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive behaviors","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306460324002247","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}
Long-term impact of maternal prenatal smoking on EEG brain activity and internalizing/externalizing problem symptoms in young adults
Objective
The objective of this study was to investigate the impact of smoking during pregnancy on the development of the child. While previous research has established its detrimental effects during early childhood, understanding potential long-term consequences into adulthood remains limited. This study specifically aimed to explore the influence of prenatal smoking exposure on brain activity and whether internalizing and externalizing symptoms are influenced by prenatal smoking exposure in a cohort of young adults.
Methods
Utilizing data from 176 participants (mean age M = 24.68, SD = 0.49) and their mothers enrolled in a longitudinal risk study (MARS), we employed Generalized Additive Mixed Models (GAMMs) to analyze electroencephalography (EEG) power at rest and behavioral outcomes derived from the Young Adult-Self-Report (YASR) scales. Both covariate-unadjusted and −adjusted models were used, taking into account participant variables such as sex and age, as well as maternal factors like psychopathology and alcohol consumption, in addition to smoking and alcohol intake by the participants themselves.
Results
The study revealed a significant impact of prenatal smoking on delta and theta band power, indicating decreased slower brain activity in prenatally exposed individuals compared to unexposed counterparts. Additionally, individuals exposed to prenatal smoking exhibited significantly higher levels of externalizing behavior. While this association was strongly influenced by maternal psychopathology, the child’s gender, and the child’s own substance use, the effect on delta power band remained after adjusting for covariates.
Conclusion
The findings suggest that prenatal smoking exposure may have enduring effects on brain activity patterns in young adulthood. Conversely, the influence on externalizing behaviors depended on familial factors (maternal psychopathology) and the lifestyle of the individual (substance use).
期刊介绍：
Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings.
Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.
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