未经治疗的内侧半月板斜面损伤对内侧半月板组织学恶化结果的影响：猪前十字韧带重建模型研究

IF 2 Q2 ORTHOPEDICS Journal of Experimental Orthopaedics Pub Date : 2024-09-27 DOI:10.1002/jeo2.70027

Akihiro Saitsu, Tsuneari Takahashi, Hibiki Kakiage, Kazuhisa Hatayama, Tatsuya Kubo, Yuta Matsumoto, Katsushi Takeshita

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摘要

目的在猪模型中评估未经处理的内侧半月板斜面损伤（MMRL）对前交叉韧带（ACL）重建后肌腱移植的影响以及内侧半月板（MM）的组织学结果。方法将 17 头猪分为两组：(1) 未经 MMRL 处理组（UM 组，n = 9）和 (2) 完整 MM 组（n = 8），术后 12 周安乐死。然后对这些试样进行周期性测试并加载至失效。分析了循环加载下平移的侧向差异（SSD）和结构特性。还对 MM 进行了组织学评估。结果在循环测试期间，平移的 SSD（UM 组，0.3 ± 0.4 mm；完整 MM 组，0.1 ± 1.4 mm）、上屈服载荷（UM 组，476.3 ± 399.9 N；完整 MM 组，643.2 ± 302.9 N）、最大载荷（UM 组，476.3 ± 399.9 N；完整 MM 组，643.2 ± 302.9 N）和结构特性均无明显差异。9 N）、最大载荷（UM 组，539.5 ± 265.8 N；完整 MM 组，705.8 ± 282.6 N）、线性刚度（UM 组，63.5 ± 39.0 N/mm；完整 MM 组，73.7 ± 60.1 N/mm）和破坏时伸长率（UM 组，-4.6 ± 16.3 mm；完整 MM 组，2.3 ± 6.6 mm）。然而，与完整 MM 组相比，UM 组的改良 Mankin 组织学分级评分（1.8 ± 0.4 [1-2] vs. 0 ± 0 [0]；p < 0.001）和改良 Copenhaver 分类评分（6.6 ± 2.4 [2-9] vs. 0.7 ± 1.1 [0-3]；p < 0.001）明显较差。结论未经治疗的MMRL术后组织学恶化。证据等级 IV 级。

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Effects of an untreated medial meniscal ramp lesion on histological deterioration findings of the medial meniscus: A study in a porcine anterior cruciate ligament reconstruction model

Purpose

To evaluate the effect of untreated medial meniscal ramp lesions (MMRLs) on the tendon graft after anterior cruciate ligament (ACL) reconstruction and histological findings of medial meniscus (MM) in a porcine a model.

Methods

A total of 17 pigs were divided into two groups: (1) the untreated MMRL group (UM group, n = 9) and (2) intact MM group (n = 8) and euthanized 12 weeks after surgery. The specimens were then tested cyclically and loaded to failure. Side-to-side differences (SSDs) in translation under cyclic loading and structural properties were analyzed. Histological evaluation of the MM was also performed.

Results

No significant differences in the SSD in translation during the cyclic testing (UM group, 0.3 ± 0.4 mm; intact MM group, 0.1 ± 1.4 mm), upper yield load (UM group, 476.3 ± 399.9 N; intact MM group, 643.2 ± 302.9 N), maximum load (UM group, 539.5 ± 265.8 N; intact MM group, 705.8 ± 282.6 N), linear stiffness (UM group, 63.5 ± 39.0 N/mm; intact MM group, 73.7 ± 60.1 N/mm) and elongation at failure (UM group, −4.6 ± 16.3 mm; intact MM group, 2.3 ± 6.6 mm) were observed. However, the UM group had significantly worse Modified Mankin's histological grading scores (1.8 ± 0.4 [1–2] vs. 0 ± 0 [0]; p < 0.001) and Modified Copenhaver classification scores (6.6 ± 2.4 [2–9] vs. 0.7 ± 1.1 [0–3]; p < 0.001) than did the intact MM group.