与协调重置深部脑刺激治疗效果相关的丘脑下和丘脑下-皮层一致性降低

IF 6.7 1区医学 Q1 NEUROSCIENCES NPJ Parkinson's Disease Pub Date : 2024-09-28 DOI:10.1038/s41531-024-00797-w

Lvpiao Zheng, Ziling Luo, Biswaranjan Mohanty, Sana Amoozegar, Luke A. Johnson, Jerrold L. Vitek, Jing Wang

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引用次数: 0

摘要

协调复位深部脑刺激（CR DBS）是治疗帕金森病（PD）的一种很有前景的方法，据推测它能使神经元群失调。然而，很少有体内数据能探究这一假设。在帕金森病非人灵长类动物中，我们发现眼下丘 CR DBS 抑制了眼下丘和皮层-眼下丘在 beta 波段的一致性，这与运动改善相关。我们的研究结果支持 CR DBS 的去同步化机制，并提出了闭环 CR DBS 的潜在生物标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.