Health state utility is substantially reduced with an increasing burden of patient-reported symptoms in eosinophilic esophagitis.

BACKGROUND We aimed to estimate health state utility in eosinophilic esophagitis (EoE) by histologic activity and assess association with disease parameters. METHODS In this cross-sectional study, we measured health state utility by time trade-off and assessed symptoms with the EoE Symptom Activity Index (EEsAI). RESULTS In 51 adults with EoE, mean utility was 0.91 (95% CI 0.86, 0.95). Utility was numerically worse in patients with dilation or a smaller stricture diameter. With each ten-point improvement in EEsAI, utility increased by 0.03 (95% CI 0.01, 0.05). DISCUSSION EoE is associated with reduced health state utility, with symptoms most strongly predicting valuation.