Sahera Dirajlal-Fargo, Melica Nikahd, Kate Ailstock, Manjunath Manubolu, Victor Musiime, Cissy Kityo, Grace A McComsey, Nicholas T Funderburg
{"title":"乌干达感染艾滋病毒的青年体内脂质体的变化与免疫激活和亚临床血管疾病有关","authors":"Sahera Dirajlal-Fargo, Melica Nikahd, Kate Ailstock, Manjunath Manubolu, Victor Musiime, Cissy Kityo, Grace A McComsey, Nicholas T Funderburg","doi":"10.1093/infdis/jiae461","DOIUrl":null,"url":null,"abstract":"This study examined the changes in the lipidome and associations with immune activation and cardiovascular disease markers in youth living with perinatally acquired HIV (YPHIV). The serum lipidome was measured in ART-treated YPHIV (n=100) and HIV- Ugandan children (n=98) Plasma markers of systemic inflammation, monocyte activation, gut integrity, T cell activation, as well as and common carotid artery intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated at baseline and 96 weeks. Overall, median age was 12 years,52% were females. Total cholesterol, LDL, and HDL were similar between the groups, however, the concentrations of ceramides, diacylglycerols, free fatty acids, lysophysophatidylcholines and phosphatidylcholines, were higher in YPHIV (P≤0.03). Increases in phosphatidylethanolamine (16:0 and 18:0) correlated with increases in sCD163, OxLDL, CRP, IFAB and PWV in PHIV (r≥0.3). YPHIV, successfully suppressed on ART, have elevated lipid species that are associated with CVD, specificallypalmitic acid (C16:0) and stearic acid (C18:0).","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Changes in the lipidome are associated with immune activation and subclinical vascular disease in youth with HIV in Uganda\",\"authors\":\"Sahera Dirajlal-Fargo, Melica Nikahd, Kate Ailstock, Manjunath Manubolu, Victor Musiime, Cissy Kityo, Grace A McComsey, Nicholas T Funderburg\",\"doi\":\"10.1093/infdis/jiae461\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study examined the changes in the lipidome and associations with immune activation and cardiovascular disease markers in youth living with perinatally acquired HIV (YPHIV). The serum lipidome was measured in ART-treated YPHIV (n=100) and HIV- Ugandan children (n=98) Plasma markers of systemic inflammation, monocyte activation, gut integrity, T cell activation, as well as and common carotid artery intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated at baseline and 96 weeks. Overall, median age was 12 years,52% were females. Total cholesterol, LDL, and HDL were similar between the groups, however, the concentrations of ceramides, diacylglycerols, free fatty acids, lysophysophatidylcholines and phosphatidylcholines, were higher in YPHIV (P≤0.03). Increases in phosphatidylethanolamine (16:0 and 18:0) correlated with increases in sCD163, OxLDL, CRP, IFAB and PWV in PHIV (r≥0.3). YPHIV, successfully suppressed on ART, have elevated lipid species that are associated with CVD, specificallypalmitic acid (C16:0) and stearic acid (C18:0).\",\"PeriodicalId\":501010,\"journal\":{\"name\":\"The Journal of Infectious Diseases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiae461\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiae461","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Changes in the lipidome are associated with immune activation and subclinical vascular disease in youth with HIV in Uganda
This study examined the changes in the lipidome and associations with immune activation and cardiovascular disease markers in youth living with perinatally acquired HIV (YPHIV). The serum lipidome was measured in ART-treated YPHIV (n=100) and HIV- Ugandan children (n=98) Plasma markers of systemic inflammation, monocyte activation, gut integrity, T cell activation, as well as and common carotid artery intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated at baseline and 96 weeks. Overall, median age was 12 years,52% were females. Total cholesterol, LDL, and HDL were similar between the groups, however, the concentrations of ceramides, diacylglycerols, free fatty acids, lysophysophatidylcholines and phosphatidylcholines, were higher in YPHIV (P≤0.03). Increases in phosphatidylethanolamine (16:0 and 18:0) correlated with increases in sCD163, OxLDL, CRP, IFAB and PWV in PHIV (r≥0.3). YPHIV, successfully suppressed on ART, have elevated lipid species that are associated with CVD, specificallypalmitic acid (C16:0) and stearic acid (C18:0).