2024 年 4 月美国 8 个月以下婴儿的母体呼吸道合胞病毒疫苗接种和呼吸道合胞病毒抗体 (Nirsevimab) 接收情况。

Hilda Razzaghi,Emma Garacci,Katherine E Kahn,Megan C Lindley,Jefferson M Jones,Shannon Stokley,Kayla Calhoun,Carla L Black
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摘要

呼吸道合胞病毒 (RSV) 是导致美国婴儿住院的最常见原因。美国疾病预防控制中心建议孕妇接种 RSV 疫苗,或为年龄小于 8 个月的婴儿注射 RSV 抗体(nirsevimab),以预防婴儿患上 RSV 下呼吸道疾病。为了确定 2023-24 年 RSV 流行季节的母婴 RSV 免疫覆盖率,疾病预防控制中心在 2024 年 3 月 26 日至 4 月 11 日期间进行了一次互联网小组调查。在 2023 年 9 月至 2024 年 1 月期间妊娠 32-36 周的 678 名妇女中,32.6% 的人表示在怀孕期间的任何时候接种过 RSV 疫苗。在 2023 年 8 月至 2024 年 3 月期间有婴儿出生的 866 名妇女中,有 44.6% 的人报告其婴儿接受过 nirsevimab 治疗。总体而言,55.8% 的婴儿受到了母体 RSV 疫苗、尼舍维单抗或两者的保护。医护人员推荐母体接种疫苗或婴儿接种尼舍维姆与较高的免疫覆盖率有关,而没有医护人员推荐则是没有接种 RSV 疫苗的主要原因。肯定或可能不为婴儿接种 nirsevimab 的主要原因是担心婴儿的长期安全性。支持医疗服务提供者提出 RSV 预防建议并与患者进行信息交流的活动可能会提高婴儿预防严重 RSV 疾病的比例。美国疾病预防控制中心和美国妇产科医师学会拥有各种资源,可帮助医疗服务提供者有效宣传免疫接种的重要性。
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Maternal Respiratory Syncytial Virus Vaccination and Receipt of Respiratory Syncytial Virus Antibody (Nirsevimab) by Infants Aged <8 Months - United States, April 2024.
Respiratory syncytial virus (RSV) is the most common cause of hospitalization among U.S. infants. CDC recommends RSV vaccination for pregnant persons or administration of RSV antibody (nirsevimab) to infants aged <8 months to prevent RSV lower respiratory tract disease among infants. To determine maternal and infant RSV immunization coverage for the 2023-24 RSV season, CDC conducted an Internet panel survey during March 26-April 11, 2024. Among 678 women at 32-36 weeks' gestation during September 2023-January 2024, 32.6% reported receipt of an RSV vaccine any time during pregnancy. Among 866 women with an infant born during August 2023-March 2024, 44.6% reported receipt of nirsevimab by the infant. Overall, 55.8% of infants were protected by maternal RSV vaccine, nirsevimab, or both. Provider recommendation for maternal vaccination or infant nirsevimab was associated with higher immunization coverage, whereas lack of a provider recommendation was the main reason for not getting RSV immunization. The main reason for definitely or probably not getting nirsevimab for infants was concern about the long-term safety for the infant. Activities supporting providers to make RSV prevention recommendations and have informative conversations with patients might increase the proportion of infants protected against severe RSV disease. CDC and the American College of Obstetricians and Gynecologists have resources to assist providers in effectively communicating the importance of immunization.
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