具有独特细胞内化功能的水溶性芳香族纳米带

IF 19.3 1区材料科学 Q1 CHEMISTRY, PHYSICAL ACS Energy Letters Pub Date : 2024-09-30 DOI:10.1002/anie.202414645

Konstantin Günther, Hideya Kono, Hiroki Shudo, Daisuke Shimizu, Reika Isoda, Masayoshi Nakamura, Akiko Yagi, Kazuma Amaike, Kenichiro Itami

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引用次数: 0

摘要

我们合成了一种水溶性芳香族纳米带，并研究了它在 HeLa 细胞中的细胞吸收行为。母体亚甲基桥接[6]环联苯（[6]MCPP）的后期官能化仅需一个反应步骤就能提供一种易于获得的炔烃官能化纳米带。炔基取代的 [6]MCPP 在铜催化下，通过使用染料连接的叠氮化物进行叠氮-炔基环加成反应，得到水溶性芳香族纳米带。在 HeLa 细胞中对合成的纳米带进行的细胞成像实验显示了细胞摄取的停停走走的动态变化。用对照分子进行的类似实验和理论研究表明，纳米带独特的动力学特性来自于带状结构。

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Water-Soluble Aromatic Nanobelt with Unique Cellular Internalization

A water-soluble aromatic nanobelt was synthesized, and its cellular uptake behavior in HeLa cells was investigated. The late-stage functionalization of the parent methylene-bridged [6]cycloparaphenylene ([6]MCPP) provided an easily accessible alkyne-functionalized nanobelt in a single reaction step. The alkyne-substituted [6]MCPP was subjected to Cu-catalyzed azide–alkyne cycloaddition by using a dye-attached azide to obtain a water-soluble aromatic nanobelt. Cell-imaging experiments on the synthesized nanobelt in HeLa cells revealed stop-and-go cellular uptake dynamics. Similar experiments with control molecules and theoretical studies indicated that the unique dynamics of the nanobelt was derived from the belt-shaped structure.

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来源期刊

ACS Energy Letters Energy-Renewable Energy, Sustainability and the Environment

CiteScore

31.20

自引率

5.00%

发文量

469

审稿时长

1 months

期刊介绍： ACS Energy Letters is a monthly journal that publishes papers reporting new scientific advances in energy research. The journal focuses on topics that are of interest to scientists working in the fundamental and applied sciences. Rapid publication is a central criterion for acceptance, and the journal is known for its quick publication times, with an average of 4-6 weeks from submission to web publication in As Soon As Publishable format. ACS Energy Letters is ranked as the number one journal in the Web of Science Electrochemistry category. It also ranks within the top 10 journals for Physical Chemistry, Energy & Fuels, and Nanoscience & Nanotechnology. The journal offers several types of articles, including Letters, Energy Express, Perspectives, Reviews, Editorials, Viewpoints and Energy Focus. Additionally, authors have the option to submit videos that summarize or support the information presented in a Perspective or Review article, which can be highlighted on the journal's website. ACS Energy Letters is abstracted and indexed in Chemical Abstracts Service/SciFinder, EBSCO-summon, PubMed, Web of Science, Scopus and Portico.