电离辐射与皮肤癌--现有证据综述。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-26 DOI:10.1088/1361-6498/ad7ff5
Luca Caramenti, Joachim Breckow, Guido Hildebrandt, Hans Drexler, Beate Volkmer, Michael Hauptmann
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引用次数: 0

摘要

皮肤癌是辐射防护面临的一项挑战,因为它非常常见,涉及人体最大的器官,暴露于环境压力,包括电离辐射。最常见的亚型,基底细胞癌(BCC)和鳞状细胞癌(SCC)的死亡率非常低。目前在辐射防护中对皮肤癌的考虑主要基于 20 世纪 90 年代的数据,这些数据表明,电离辐射可能诱发 BCC,SCC 与电离辐射的关系较弱,而恶性黑色素瘤(MM)不被认为是电离辐射诱发的。在对 1990 年至 2023 年间的证据进行半系统性回顾时,我们以滚雪球的方式收集了 19 篇索引文章。我们确定了 29 篇文章,这些文章提供了皮肤癌与电离辐射照射之间潜在剂量-反应关系的信息,并评估了因果关系的证据。辐照情况包括原子弹爆炸幸存者、治疗性和职业性辐照(航空公司、核设施和医疗设施)以及暴露于氡的居民。目前还没有流行病学证据表明 MM 或 SCC 是由电离辐射引起的。唯一有证据表明其因果关系的皮肤癌类型是 BCC,而且证据仅限于 0.5 Gy 以上的辐照,单位剂量的风险水平范围很广。因此,电离辐射诱发的皮肤癌仅指 BCC,且仅在辐照水平超过当今绝大多数人所经历的辐照水平的情况下。
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Ionizing radiation and skin cancer - a review of current evidence.

Cancer of the skin represents a challenge for radiological protection, as it is very common and involves the largest organ of the human body, which is exposed to environmental stress, including ionizing radiation. The most common subtypes, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) have very low mortality. Current consideration of skin cancer in radiological protection is mainly based on data from the 1990s, which indicate that BCC may be induced by ionizing radiation, SCC is only weakly associated with ionizing radiation, and malignant melanoma (MM) is not considered as ionizing radiation-induced. In a semi-systematic review of the evidence between 1990 and 2023, we snowballed 19 index articles. We identified 29 articles with information on a potential dose-response relationship between skin cancer and ionizing radiation exposure and assessed the evidence for a causal association. Exposure situations included a-bomb survivors, therapeutic and occupational exposure (airlines, nuclear and medical facilities) and residents exposed to radon. There is currently no epidemiological evidence that MM or SCC are caused by ionizing radiation. The only skin cancer type with evidence for a causal relationship is BCC, and evidence is limited to exposures above 0.5 Gy with a wide range of risk levels per dose. Thus, ionizing radiation-inducible skin cancer refers to BCC only and only at levels of exposure beyond those experienced by the vast majority of people exposed today.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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