机械血栓切除术前的炎症反应对中风患者预后的影响。

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2024-09-30 DOI:10.18071/isz.77.0323

Emrah Aytaç, Ferhat Balgetir, Şule Kavak Genç, Murat Gönen, Hasan Dogan, Cetin Kursad Akpinar

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引用次数: 0

摘要

背景和目的：机械性血栓切除术是急性卒中最重要的治疗方式；尽管成功切除了血栓，但相当一部分患者无法获得良好的功能预后。本研究探讨了入院时中性粒细胞淋巴细胞比值（NLR）对成功再通患者功能预后的影响：方法：对因前系统大血管闭塞而接受机械血栓切除术的患者进行回顾性分析，并与成功再通患者的入院NLR值和3个月临床改良Rankin量表（mRS）评分进行比较：在规定时间内接受血栓切除术的126名患者中，有97名患者成功再通。经计算，总的成功再通率为 77%。研究发现，mRS≤2（n=65）患者的平均 NLR 明显低于 mRS≥3（n=32）患者（p<0.001）。美国国立卫生研究院卒中量表（NIHSS）值与 NLR 之间存在微弱的显着相关性（r= 0.315，p=.002）：NLR值与急性血栓切除术患者的无效再通有关。因此，我们认为在血栓切除术前抑制炎症会增加血栓切除术成功的几率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of inflammatory response before mechanical thrombectomy on prognosis in stroke patients.

Background and purpose:

Mechanical thrombectomy is the most important treatment modality in acute stroke; despite successful thrombectomy, good functional outcome is not achieved in a significant proportion of patients. This study examined the effect of neutrophil lymphocyte ratio (NLR) values at admission on functional outcomes in successfully recanalized patients.

Methods:

Patients who underwent mechanical thrombectomy due to anterior system major vessel occlusion were retrospectively analyzed and compared with the admission NLR values and 3-month clinical modified Rankin Scale (mRS) scores of successfully recanalized patients.

Results:

Of a total of 126 patients who underwent thrombectomy within the specified period, 97 patients with successful recanalization were included in the study. The overall successful recanalization rate was calculated as 77%. The mean NLR of patients with mRS ≤2 (n=65) was found to be significantly lower than patients with mRS≥3 (n=32) (p<0.001). A weak and significant correlation was found between National Institutes of Health Stroke Scale (NIHSS) value and NLR (r= 0.315, p=.002).

Conclusion:

NLR value has been found to be associated with futile recanalization in mechanical thrombectomy patients. Therefore, we think that suppression of inflammation before thrombectomy will increase the chance of successful thrombectomy.

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来源期刊

Ideggyogyaszati Szemle-Clinical Neuroscience CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Clinical Neuroscience (Ideggyógyászati Szemle) is to provide a forum for the exchange of clinical and scientific information for a multidisciplinary community. The Clinical Neuroscience will be of primary interest to neurologists, neurosurgeons, psychiatrist and clinical specialized psycholigists, neuroradiologists and clinical neurophysiologists, but original works in basic or computer science, epidemiology, pharmacology, etc., relating to the clinical practice with involvement of the central nervous system are also welcome.