催产素保护大鼠免受辐射造成的肺损伤

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-08-29 DOI:10.3390/tomography10090101

Ahmet Kayalı, Duygu Burcu Arda, Ejder Saylav Bora, Yiğit Uyanikgil, Özüm Atasoy, Oytun Erbaş

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引用次数: 0

摘要

背景：放射性肺损伤（RILI）是胸部放疗的一种严重副作用，可导致急性放射性肺炎（RP）和慢性肺纤维化（PF）。尽管采取了各种干预措施，但仍没有有效的方案来预防肺炎。催产素（OT）以其抗炎、抗细胞凋亡和抗氧化特性而闻名，但其在减轻 RILI 方面的潜力尚未得到探讨：本研究涉及 24 只雌性 Wistar 白化大鼠，分为三组：对照组、放射线 (RAD) + 生理盐水组和 RAD + OT 组。RAD 组接受 18 Gy 全胸照射。RAD + OT 组腹腔注射 OT（0.1 毫克/千克/天），连续治疗 16 周。进行了计算机断层扫描（CT）成像、组织病理学、生化和血气分析，以评估肺组织损伤和炎症情况：组织病理学检查显示，与 RAD + 生理盐水组相比，RAD + OT 组的肺泡壁增厚、炎症和血管变化明显减少。生化分析显示，RAD + 催产素组的 TGF-beta、VEGF 和 PDGF 水平降低，BMP-7 和前列环素水平升高（p < 0.05）。形态计量分析表明，纤维化、水肿和免疫细胞浸润明显减少。CT 成像显示，RAD + 催产素组的肺实质密度接近正常（p < 0.001）：结论：催产素能明显减轻辐射诱导的大鼠肺炎，这意味着催产素具有预防和治疗 RILI 的潜力。

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Oxytocin: A Shield against Radiation-Induced Lung Injury in Rats.

Background: Radiation-induced lung injury (RILI), a serious side effect of thoracic radiotherapy, can lead to acute radiation pneumonitis (RP) and chronic pulmonary fibrosis (PF). Despite various interventions, no effective protocol exists to prevent pneumonitis. Oxytocin (OT), known for its anti-inflammatory, antiapoptotic, and antioxidant properties, has not been explored for its potential in mitigating RILI.

Materials and methods: This study involved 24 female Wistar albino rats, divided into three groups: control group, radiation (RAD) + saline, and RAD + OT. The RAD groups received 18 Gy of whole-thorax irradiation. The RAD + OT group was treated with OT (0.1 mg/kg/day) intraperitoneally for 16 weeks. Computerizing tomography (CT) imaging and histopathological, biochemical, and blood gas analyses were performed to assess lung tissue damage and inflammation.

Results: Histopathological examination showed significant reduction in alveolar wall thickening, inflammation, and vascular changes in the RAD + OT group compared to the RAD + saline group. Biochemical analysis revealed decreased levels of TGF-beta, VEGF, and PDGF, and increased BMP-7 and prostacyclin in the RAD + oxytocin group (p < 0.05). Morphometric analysis indicated significant reductions in fibrosis, edema, and immune cell infiltration. CT imaging demonstrated near-normal lung parenchyma density in the RAD + oxytocin group (p < 0.001).

Conclusion: Oxytocin administration significantly mitigates radiation-induced pneumonitis in rats, implying that is has potential as a therapeutic agent for preventing and treating RILI.

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.