Akhila Alapati, Saleema Kherani, Tedi Begaj, Timothy M Janetos, Kevin Zhang, Anjum Koreishi, Debra A Goldstein
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引用次数: 0
摘要
目的：确定黄斑体积扫描的光学相干断层扫描（OCT）厚度值是否可用于检测葡萄膜炎性视网膜血管炎：方法：对非感染性视网膜血管炎患者进行回顾性研究。方法：对非感染性视网膜血管炎患者进行回顾性研究，获得荧光素血管造影（FA）和61线OCT黄斑体积扫描，并覆盖早期治疗糖尿病视网膜病变研究（ETDRS）网格。分析了 1 毫米和 6 毫米 ETDRS 环值与后极部血管炎之间的相关性。采用线性纵向模型评估全局视网膜血管炎评分与 OCT 黄斑厚度参数之间的关系：结果：共纳入 54 名患者的 99 只眼睛。结果：共纳入 54 名患者的 99 只眼睛，分析了 460 对 OCT 和荧光素血管造影。黄斑中心厚度（1 毫米）与后极血管炎呈弱相关（相关系数 [rho]=0.09, p=0.06）。6 毫米环平均值（rho=0.11，p=0.018）和上下（S/I）6 毫米环平均值（rho=0.13，p=0.006）与后极渗漏密切相关。纵向模型显示，S/I 6 毫米环值与后极、中周和远周的血管炎相关（p结论：基于 OCT 的黄斑体积厚度可检测葡萄膜视网膜血管炎，并有助于监测疾病活动。
Macular Volume Scan as a Marker of Angiographic Uveitic Retinal Vasculitis: A Retrospective Longitudinal Study.
Purpose: To determine whether optical coherence tomography (OCT) thickness values from macular volume scans can be used to detect uveitic retinal vasculitis.
Methods: Retrospective study of patients with noninfectious retinal vasculitis. Fluorescein angiogram (FA) and 61-line OCT macular volume scans with an overlying Early Treatment Diabetic Retinopathy study (ETDRS) grid were obtained. Correlation between 1mm and 6mm ETDRS ring values and posterior pole vasculitis was analyzed. A linear longitudinal model was used to assess the relationship between global retinal vasculitis scores and OCT macular thickness parameters.
Results: Ninety-nine eyes of 54 patients were included. A total of 460 OCT and fluorescein angiogram pairs were analyzed. Central (1mm) macular thickness was weakly correlated with posterior pole vasculitis (correlation coefficient [rho]=0.09, p=0.06). Both the mean 6mm ring (rho=0.11, p=0.018) and the average of the superior and inferior (S/I) 6mm ring values (rho=0.13, p=0.006) were strongly correlated with posterior pole leakage. The longitudinal model showed that S/I 6mm ring values are associated with vasculitis in the posterior pole, mid and far periphery (p<0.0001).
Conclusions: OCT-based macular volume thickness can detect uveitic retinal vasculitis and aid in monitoring disease activity.
期刊介绍：
RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice.
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Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.
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