采用体外放射治疗和高剂量率近距离放射治疗的唇部 "高危 "肿瘤：长期疗效。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-09-26 DOI:10.1002/hed.27936

Claes Mercke, Signe Friesland, Anders Berglund, Gun Wickart Johansson, Gregori Margolin, Michael Gubanski, Einar Björgvinsson, Josef Nilsson

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引用次数: 0

摘要

背景：放疗是治疗唇癌的一种行之有效的方法：放疗是治疗唇癌的一种行之有效的方法，可采用体外放射治疗（EBRT）或近距离放射治疗（BT）：本研究评估了 101 名不适合手术的唇癌患者接受 EBRT 和 BT 联合治疗后的疗效、肿瘤控制和美学效果：78例患者为鳞状细胞癌，15例患者为基底细胞癌，8例患者为其他组织类型。肿瘤为晚期：73%为T2-T4类。3年和5年的局部控制率为89%。4/56（7%）名患者接受了初治 RT，7/45（16%）名患者接受了手术，5名患者出现了局部复发。毒性较轻。在接受评估的87名患者中，9/40的患者接受了前期手术，而1/47的患者接受了初治RT（P = 0.003）。7名患者死于唇癌（7%），其中3名患者原本患有N+疾病（43%）：结论：对于不适合手术的唇部肿瘤，可以考虑联合使用EBRT和BT。

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"High-risk" tumors of the lip treated with external beam radiotherapy and high-dose-rate brachytherapy: Long-term outcome.

Background: Radiotherapy is a well-established treatment for lip cancer, with external radiotherapy (EBRT) or brachytherapy (BT).

Methods: This study evaluated outcome, tumor control, and aesthetics, for 101 patients with carcinoma of the lip, not suitable for surgery, treated with combined EBRT and BT.

Results: Squamous cell carcinoma was seen in 78 patients, basal cell carcinoma in 15, and other histologies in 8 patients. Tumors were advanced: 73% in category T2-T4. Local control at 3 and 5 years was 89%. Local failure appeared in 4/56 patients (7%) with primary RT compared to 7/45 (16%) in those with prior surgery, regional recurrence in 5 patients. Toxicity was mild. Cosmetic outcome, 87 patients evaluated, was bad for 9/40 patients with upfront surgery compared to 1/47 for primary RT patients (p = 0.003). Seven patients died from lip cancer (7%), three with originally N+ disease (43%).

Conclusions: Combined EBRT and BT could be considered for lip tumors not candidates for surgery.

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