Alhadi Almangush, Lauri Jouhi, Caj Haglund, Jaana Hagström, Antti A Mäkitie, Ilmo Leivo
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引用次数: 0
摘要
背景：近年来，肿瘤微环境（TME）对预后影响的评估受到关注。我们介绍了一种基于TME的口咽鳞状细胞癌（OPSCC）风险分层方法：材料和方法：共纳入了182名在赫尔辛基大学医院接受治疗的口咽鳞状细胞癌患者。通过苏木精和伊红染色切片评估肿瘤间质比率和基质肿瘤浸润淋巴细胞，设计了基于TME的风险分层：在多变量分析中，基于TME的风险分层与无病生存率低有关，危险比（HR）为2.68（95% CI 1.11-6.48，P = 0.029）。此外，建议的风险分层与疾病特异性生存率低（HR 2.687，95% CI 1.28-5.66，p = 0.009）和总生存率低（HR 2.21，95% CI 1.23-3.99，p = 0.008）相关：我们基于TME的风险分层提供了一个强大的预后工具，可与肿瘤相关预后标志物一起用于OPSCC的日常治疗计划。
Tumor Microenvironment-Based Risk Stratification of Oropharyngeal Squamous Cell Carcinoma.
Background: Evaluation of the prognostic impact of tumor microenvironment (TME) has received attention in recent years. We introduce a TME-based risk stratification for oropharyngeal squamous cell carcinoma (OPSCC).
Material and methods: A total of 182 patients treated for OPSCC at the Helsinki University Hospital were included. TME-based risk stratification was designed combining tumor-stroma ratio and stromal tumor-infiltrating lymphocytes assessed in hematoxylin and eosin-stained sections.
Results: In multivariable analysis, TME-based risk stratification associated with poor disease-free survival with a hazard ratio (HR) of 2.68 (95% CI 1.11-6.48, p = 0.029). In addition, the proposed risk stratification was associated with poor disease-specific survival (HR 2.687, 95% CI 1.28-5.66, p = 0.009) and poor overall survival (HR 2.21, 95% CI 1.23-3.99, p = 0.008).
Conclusion: Our TME-based risk stratification provides a powerful prognostic tool that can be used in daily treatment planning of OPSCC together with tumor-related prognostic markers.
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