Mihaela-Andreea Podeanu, Ștefănița Bianca Vintilescu, Claudiu Marinel Ionele, Raluca Elena Sandu, Carmen Elena Niculescu, Mirela-Marinela Florescu, Mioara Desdemona Stepan
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According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS.</p><p><strong>Results: </strong>The MetS positive group had higher values of TG/HDL-C (<i>p</i> < 0.001), TC/HDL-C (<i>p</i> < 0.001), MHR (<i>p</i> = 0.015), LHR (<i>p</i> = 0.001), NHR (<i>p</i> = 0.001), atherogenic index of plasma (<i>p</i> < 0.001), and PHR (<i>p</i> < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity.</p><p><strong>Conclusions: </strong>In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11433473/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome.\",\"authors\":\"Mihaela-Andreea Podeanu, Ștefănița Bianca Vintilescu, Claudiu Marinel Ionele, Raluca Elena Sandu, Carmen Elena Niculescu, Mirela-Marinela Florescu, Mioara Desdemona Stepan\",\"doi\":\"10.3390/life14091206\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community.</p><p><strong>Objectives: </strong>The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents.</p><p><strong>Methods: </strong>We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS.</p><p><strong>Results: </strong>The MetS positive group had higher values of TG/HDL-C (<i>p</i> < 0.001), TC/HDL-C (<i>p</i> < 0.001), MHR (<i>p</i> = 0.015), LHR (<i>p</i> = 0.001), NHR (<i>p</i> = 0.001), atherogenic index of plasma (<i>p</i> < 0.001), and PHR (<i>p</i> < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. 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The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome.
Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community.
Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents.
Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS.
Results: The MetS positive group had higher values of TG/HDL-C (p < 0.001), TC/HDL-C (p < 0.001), MHR (p = 0.015), LHR (p = 0.001), NHR (p = 0.001), atherogenic index of plasma (p < 0.001), and PHR (p < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity.
Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.
Life-BaselBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
4.30
自引率
6.20%
发文量
1798
审稿时长
11 weeks
期刊介绍:
Life (ISSN 2075-1729) is an international, peer-reviewed open access journal of scientific studies related to fundamental themes in Life Sciences, especially those concerned with the origins of life and evolution of biosystems. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers.