喉部杓间颗粒细胞瘤--罕见病例报告

Sakthimurugan Sankar, Raadhika Shree N, Subagar Anbarasan, Jayaganesh P
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摘要

颗粒细胞瘤(GCT)是一种不常见的肿瘤,通常起源于许旺细胞,颗粒状细胞质是其标志性特征。喉颗粒细胞瘤占病例的3%至10%,由于与鳞状细胞癌相似,给诊断带来了挑战。我们介绍了一例因咽喉疼痛而被诊断为喉 GCT 的 46 岁男性病例。组织病理学检查和免疫组化证实了诊断结果。喉 GCT 通常表现为小而坚硬的粘膜下结节,与声带息肉难以区分。诊断依赖于组织学检查,其特征包括嗜酸性颗粒胞质和特异性标记物染色阳性。恶性转化虽然罕见,但需要警惕监测和准确诊断。治疗包括彻底手术切除和长期随访以检测复发。本病例强调了认识和准确诊断在治疗喉GCT中的重要性,可确保及时干预和最佳的患者预后。
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Inter Arytenoid Granular Cell Tumor of Larynx-A Rare Case Report.

Granular cell tumors (GCTs) are uncommon neoplasms, often originating from Schwann cells, with granular cytoplasm being a hallmark feature. Laryngeal GCTs, comprising 3% to 10% of cases, present diagnostic challenges due to their resemblance to squamous cell carcinoma. We present a case of a 46-year-old male with throat pain, diagnosed with a laryngeal GCT. Histopathological examination and immunohistochemistry confirmed the diagnosis. Laryngeal GCTs typically manifest as small, firm submucosal nodules, posing challenges in differentiation from vocal fold polyps. Diagnosis relies on histological examination, with characteristic features including eosinophilic granular cytoplasm and positive staining for specific markers. Malignant transformation, though rare, necessitates vigilant monitoring and accurate diagnosis. Treatment involves complete surgical excision with long-term follow-up to detect recurrence. This case underscores the importance of awareness and accurate diagnosis in managing laryngeal GCTs, ensuring timely intervention and optimal patient outcomes.

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