饮食模式与乳腺癌风险:KCPS-II 队列研究。

Ji-Young Lee, Hae In Cho, Heejin Kimm
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引用次数: 0

摘要

目的:关于膳食模式在乳腺癌发病中的作用,证据并不一致。在这项研究中,我们利用大规模队列[韩国癌症预防研究-II(KCPS-II)]来研究韩国女性的饮食模式与乳腺癌风险之间的关系:通过因子分析得出了韩国癌症预防研究-II(KCPS-II)中 14 807 名女性的膳食模式,并在随访期间确诊了 135 例乳腺癌患者。采用 Cox 比例模型估算乳腺癌风险的危险比(HRs)和 95% 的置信区间(CIs):结果:确定了以下三种主要饮食模式:结果:确定了以下三种主要饮食模式:"韩国饮食模式"(泡菜、蔬菜和大米的高摄入量);"甜饮食模式"(苏打水和糖的高摄入量);以及 "新(类似西方)饮食模式"(乳制品、鸡蛋、油、水果和面包的高摄入量)。在对潜在的混杂因素进行调整后,韩国饮食模式(与最低三分位数相比,最高三分位数的 HR 为 1.04;95% CI 为 0.53-2.06)和甜食饮食模式都与乳腺癌风险无关。与此相反,新型(类西式)膳食模式被发现与乳腺癌风险的增加显著相关,与最低三分位数相比,第二三分位数的 HR(95% CI)为 1.01(0.65-1.60),第三三分位数的 HR 为 1.61(1.04-2.50)。根据绝经状况进行分层后,只有绝经前妇女的第三分层与最低分层相比才具有统计学意义(HR 1.69;95% CI 1.06-2.68;P = 0.028)。在绝经前或绝经后妇女中,均未观察到韩式或甜食饮食模式与乳腺癌之间存在明显关联:我们的研究结果表明,更多地摄入新式(类似西方的)饮食与乳腺癌风险的增加有关,因此为韩国妇女提供了一种潜在的预防策略。
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Dietary Patterns and Breast Cancer Risk: A KCPS-II Cohort Study.

Objective: There have been inconsistencies in the evidence for a role of dietary patterns in the development of breast cancer. In this study, we used a large-scale cohort [Korean Cancer Prevention Study-II (KCPS-II)] to examine the association between dietary patterns and breast cancer risk in Korean women.

Materials and methods: The dietary patterns of 14,807 women from the KCPS-II were derived by factor analysis and 135 cases of breast cancer were diagnosed during the follow-up period. Cox proportional models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of breast cancer.

Results: The following three major dietary patterns were identified: "Korean dietary pattern" (high intake of Kimchi, vegetables, and rice); "sweet dietary pattern" (high intake of soda and sugar); and "new (Western-like) dietary pattern" (high intake of dairy products, eggs, oil, fruits, and bread). After adjusting for potential confounders, neither the Korean (HR for the highest compared with the lowest tertile, 1.04; 95% CI 0.53-2.06) nor the sweet dietary patterns were associated with the risk of breast cancer. In contrast, the new (Western-like) dietary pattern was found to be significantly associated with an increased risk of breast cancer with an HR (95% CI) of 1.01 (0.65-1.60) for the second tertile and 1.61 (1.04-2.50) for the third tertile as compared with the lowest tertile. After stratifying by menopausal status, these effects were only statistically significant among premenopausal women for the third tertile, compared with those in the bottom tertile (HR 1.69; 95% CI 1.06-2.68; p = 0.028). No significant association was observed between the Korean or sweet dietary pattern and breast cancer among either pre- or postmenopausal women.

Conclusion: Our findings revealed that a greater consumption of a new (Western-like) diet was associated with an increased breast cancer risk and consequently offer a potential prevention strategy for Korean women.

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