Lactobionic acid matrix supramolecular complexes with enhanced bioavailability and clinical efficacy as an optimal CP system†

Despite the biological activity of lactobionic acid (LBA), its low bioavailability remains a challenge in response to complex clinical needs. Aided by computer high-throughput screening and ab initio analysis, we selected betaine and mandelic acid as the right arms to synthesize supramolecular lactobionic acid (SLBA) through a proton exchange reaction, which significantly and comprehensively improved the bioavailability of LBA. Density functional theory and physicochemical characterization revealed the supramolecular characteristics and chemical stability of this coupling. The resulting SLBA has shown significant advantages over LBA in cellular, animal, and clinical trials and demonstrated enormous potential in anti-aging beauty, clinical treatment, biomedicine, and food preservation.