一家三甲医院特发性全身性癫痫成年患者血清镁水平的关系。

Mymensingh medical journal : MMJ Pub Date : 2024-10-01
F Ahmed, M Bhattacharjee, M Saiduzzaman, S S Rahman, E Mia, S Banerjee, M K Linckon
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引用次数: 0

摘要

镁在神经系统中发挥着巨大作用。特别是,脑脊液中的高镁似乎能增强神经功能,而低镁则会诱发神经元疾病。本研究旨在了解血清镁与在一家三级医院就诊的特发性全身性癫痫的关系。这项横断面比较研究于 2019 年 1 月至 2020 年 6 月在孟加拉国迈门辛医学院和医院神经内科进行,并获得了伦理批准。共有 110 名特意挑选的参与者(55 名特发性全身性癫痫患者和 55 名表面健康的非癫痫患者)参加了这项研究。血清总镁由 EMP-168 生化分析仪测定。癫痫患者的平均年龄为(33.13±9.5)岁,大多数为女性(60.0%)。癫痫患者的平均血清镁水平低于对照组(1.80±0.041 vs. 2.02±0.19 mg/dl;每月 p3),其平均血清镁水平明显低于每月发作 3 次或以下的患者。与年龄和性别匹配的健康对照组相比,癫痫患者的血清镁水平有所降低。需要对更多患者进行研究,以证实这些结果。
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Relation of Serum Magnesium Level in Adult Patients with Idiopathic Generalized Epilepsy in a Tertiary Care Hospital.

Magnesium plays a vast role in the nervous system. In particular, high magnesium in cerebrospinal fluid appears to enhance the neural functions, while low magnesium induces neuronal diseases. The aim of the study was to find out the relation of serum magnesium with idiopathic generalized epilepsy attending in a tertiary care hospital. This cross-sectional comparative study was conducted in the department of Neurology at Mymensingh Medical College and Hospital, Bangladesh from January 2019 to June 2020 following ethical approval. Total 110 purposively selected participants (55 with idiopathic generalized epilepsy and 55 non epileptic apparently healthy individuals) were enrolled in this study. Serum total Mg was measured by EMP-168 Biochemical Analyzer. Average age of epileptic individuals was 33.13±9.5 years and majority was female (60.0%). Mean serum magnesium level was lower in epileptic patients than controls (1.80±0.041 vs. 2.02±0.19 mg/dl; p<0.001). Patients with higher seizure attack (>3 per month) had significantly lower mean serum magnesium level than the patients with seizure attack three or less per month. Serum magnesium levels are reduced in epileptic patients compared to healthy age and gender matched controls. Studies involving larger numbers of patients are needed to confirm these results.

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