Hao Lin, Qiang You, Xing Wei, Zongjun Chen, Xianwei Wang
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The information herein discussed was retrieved from authoritative databases, including PubMed, Web of Science, Google Scholar, Chinese National Knowledge Infrastructure (CNKI) and so on, reviewing information published up until February of 2024. New evidence shows that osthole induces a sequence of therapeutic actions and has a moderate absorption rate and rapid metabolic characteristics. In addition, this phytoconstituent possesses potential hepatotoxicity, and caution should be exercised against the risk of the drug combination. Furthermore, given its needy solubility in aqueous medium and non-organizational targeting, novel drug delivery methods have been designed to overcome these shortcomings. 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引用次数: 0
摘要
Osthole 是一种香豆素化合物,主要提取自 Cnidium monnieri(L.),因其具有多种治疗特性而备受科学界关注。然而,它的药理机制、药代动力学和毒理效应还很不清楚。此外,奥司孔的潜在给药平台仍有待全面界定。本综述旨在系统总结与奥司孔相关的药理学、药代动力学和安全性问题的最新信息,并讨论新型给药平台的研究。本文讨论的信息来自权威数据库,包括PubMed、Web of Science、Google Scholar、中国国家知识基础设施(CNKI)等,查阅了截至2024年2月发表的信息。新证据表明,奥司孔可诱导一系列治疗作用,并具有吸收率适中、代谢迅速的特点。此外,这种植物成分还具有潜在的肝毒性,因此应谨慎对待联合用药的风险。此外,鉴于其在水介质中的溶解度较低,且不具有组织靶向性,人们设计了新型给药方法来克服这些缺点。鉴于奥司孔的特性,应在更多的综合研究中阐明其治疗功效,并探索这些功效的分子机制。
Osthole, a Coumarin from Cnidium monnieri: A Review on Its Pharmacology, Pharmacokinetics, Safety, and Innovative Drug Delivery Platforms.
Osthole, a coumarin compound mainly derived from Cnidium monnieri (L.), has attracted much interest from the scientific community owing to its multiple therapeutic properties. However, its pharmacological mechanism, pharmacokinetics, and toxicological effects are far from clear. Furthermore, the potential drug delivery platforms of osthole remain to be comprehensively delineated. The present review aimed to systematically summarize the most up-to-date information related to pharmacology, pharmacokinetics, and safety issues related to osthole, and discuss the investigations of novel drug delivery platforms. The information herein discussed was retrieved from authoritative databases, including PubMed, Web of Science, Google Scholar, Chinese National Knowledge Infrastructure (CNKI) and so on, reviewing information published up until February of 2024. New evidence shows that osthole induces a sequence of therapeutic actions and has a moderate absorption rate and rapid metabolic characteristics. In addition, this phytoconstituent possesses potential hepatotoxicity, and caution should be exercised against the risk of the drug combination. Furthermore, given its needy solubility in aqueous medium and non-organizational targeting, novel drug delivery methods have been designed to overcome these shortcomings. Given the properties of osthole, its therapeutic benefits ought to be elucidated in a greater array of comprehensive research studies, and the molecular mechanisms underlying these benefits should be explored.