Single versus double fascicular transfer for brachial plexus injuries: a systematic review and meta-analysis with meta-regression.

The primary objective of this review was to assess whether double fascicular transfer has superior outcomes compared with single fascicular transfer for reanimation of elbow flexion. In total, 58 studies including 1388 patients (mean age 29 years [SD 8]) were included. Subgroup analysis comparing the severity of brachial plexus injury (C5-C6, C5-C7, C5-C8) showed no significant difference in the recovery of MRC grade 3 and 4. The aggregated mean Disabilities of Arm, Shoulder and Hand score was 38 for the single fascicular transfer group and 27 for the double fascicular transfer group. Meta-regression controlling for level of injury showed that double fascicular transfer and C5-C6 injury were significant predictors of achieving MRC grade 3, while double fascicular transfer and shorter duration of surgical delay were significant predictors of achieving MRC grade 4. When controlling for the level of injury, double fascicular transfer is associated with a greater likelihood of achieving MRC grade 3 and 4 compared to single fascicular transfer. Overall donor site morbidity was not significantly different between single fascicular transfer and double fascicular transfer.