小鼠瘙痒模型

The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI:10.1016/j.jid.2024.08.018
Daniel Yassky, Brian S Kim
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引用次数: 0

摘要

小鼠模型是研究痒的重要临床前和生物学工具。在本文中,我们将探讨这些模型如何通过急性和慢性痒模型加深我们对痒的机制的了解。我们提供了详细的实验方案,并推荐了特定模型的实验设置,以指导研究人员开展痒研究。我们区分了什么是真正的瘙痒原,什么是导致瘙痒原释放的刺激,什么是急性瘙痒模型,什么是慢性瘙痒模型,以及小鼠模型如何捕捉人类疾病中瘙痒的各个方面。最后,我们强调了小鼠瘙痒模型如何改变了我们对患者慢性瘙痒症的理解和治疗方法的开发。
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Mouse Models of Itch.

Murine models are vital preclinical and biological tools for studying itch. In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and recommend experimental setups for specific models to guide researchers in conducting itch research. We distinguish between what constitutes a bona fide pruritogen versus a stimulus that causes pruritogen release, an acute itch model versus a chronic itch model, and how murine models can capture aspects of pruritus in human disease. Finally, we highlight how mouse models of itch have transformed our understanding and development of therapeutics for chronic pruritus in patients.

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