关于类黄酮对慢性肾脏病患者动脉僵化和氧化应激影响的试点研究。

Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis
{"title":"关于类黄酮对慢性肾脏病患者动脉僵化和氧化应激影响的试点研究。","authors":"Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis","doi":"10.5527/wjn.v13.i3.95262","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.</p><p><strong>Aim: </strong>To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.</p><p><strong>Methods: </strong>In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.</p><p><strong>Results: </strong>Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (<i>P</i> < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (<i>P</i> < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (<i>P</i> = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (<i>P</i> < 0.001), total phenolic compound (<i>P</i> = 0.001), and total antioxidant capacity (<i>P</i> = 0.013).</p><p><strong>Conclusion: </strong>Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439090/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.\",\"authors\":\"Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis\",\"doi\":\"10.5527/wjn.v13.i3.95262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.</p><p><strong>Aim: </strong>To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.</p><p><strong>Methods: </strong>In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.</p><p><strong>Results: </strong>Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (<i>P</i> < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (<i>P</i> < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (<i>P</i> = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (<i>P</i> < 0.001), total phenolic compound (<i>P</i> = 0.001), and total antioxidant capacity (<i>P</i> = 0.013).</p><p><strong>Conclusion: </strong>Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.</p>\",\"PeriodicalId\":94272,\"journal\":{\"name\":\"World journal of nephrology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439090/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of nephrology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5527/wjn.v13.i3.95262\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5527/wjn.v13.i3.95262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:目的:前瞻性研究类黄酮对慢性肾脏病(CKD)I-IV期患者动脉僵化的影响:在这项前瞻性单臂研究中,招募了患有动脉高血压和糖尿病的慢性肾脏病患者。记录了基线人口统计学、临床和实验室变量。患者每天接受富含苯酚的膳食补充剂治疗,为期 3 个月。在基线和研究结束时测量血压、动脉僵化(颈动脉-股动脉脉搏波速度、中心脉压)和氧化应激指标(蛋白质羰基、总酚化合物、总抗氧化能力):16 名患者(平均年龄 62.5 岁,87.5% 为男性)完成了研究。干预后,外周收缩压明显降低了 14 mmHg(P < 0.001)。颈动脉-股动脉脉搏波速度从 8.9 米/秒(基线)降至 8.2 米/秒(研究结束时)(P < 0.001),中心脉压从 59 毫米汞柱降至 48 毫米汞柱(P = 0.003)。类黄酮还能降低氧化应激指标,包括蛋白质羰基(P < 0.001)、总酚化合物(P = 0.001)和总抗氧化能力(P = 0.013):结论:为慢性肾脏病患者补充类黄酮有望改善血压、动脉僵化和氧化应激指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.

Background: Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.

Aim: To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.

Methods: In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.

Results: Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (P < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (P < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (P = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (P < 0.001), total phenolic compound (P = 0.001), and total antioxidant capacity (P = 0.013).

Conclusion: Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.40
自引率
0.00%
发文量
0
期刊最新文献
Challenges in predictive modelling of chronic kidney disease: A narrative review. Insights into renal and urological complications of inflammatory bowel disease. Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease. Protective effect of long-chain polyunsaturated fatty acids on hepatorenal syndrome in rats. Quality of life and psychological distress in end-stage renal disease patients undergoing hemodialysis and transplantation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1