{"title":"关于类黄酮对慢性肾脏病患者动脉僵化和氧化应激影响的试点研究。","authors":"Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis","doi":"10.5527/wjn.v13.i3.95262","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.</p><p><strong>Aim: </strong>To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.</p><p><strong>Methods: </strong>In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.</p><p><strong>Results: </strong>Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (<i>P</i> < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (<i>P</i> < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (<i>P</i> = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (<i>P</i> < 0.001), total phenolic compound (<i>P</i> = 0.001), and total antioxidant capacity (<i>P</i> = 0.013).</p><p><strong>Conclusion: </strong>Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.</p>","PeriodicalId":94272,"journal":{"name":"World journal of nephrology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439090/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.\",\"authors\":\"Anastasia Vagopoulou, Panagiotis Theofilis, Despina Karasavvidou, Nasra Haddad, Dimitris Makridis, Stergios Tzimikas, Rigas Kalaitzidis\",\"doi\":\"10.5527/wjn.v13.i3.95262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.</p><p><strong>Aim: </strong>To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.</p><p><strong>Methods: </strong>In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.</p><p><strong>Results: </strong>Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (<i>P</i> < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (<i>P</i> < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (<i>P</i> = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (<i>P</i> < 0.001), total phenolic compound (<i>P</i> = 0.001), and total antioxidant capacity (<i>P</i> = 0.013).</p><p><strong>Conclusion: </strong>Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.</p>\",\"PeriodicalId\":94272,\"journal\":{\"name\":\"World journal of nephrology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439090/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of nephrology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5527/wjn.v13.i3.95262\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5527/wjn.v13.i3.95262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.
Background: Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.
Aim: To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.
Methods: In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.
Results: Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (P < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (P < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (P = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (P < 0.001), total phenolic compound (P = 0.001), and total antioxidant capacity (P = 0.013).
Conclusion: Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.