Karina Moura Sawada, Niele Silva de Moraes, Lara Miguel Quirino Araújo, Fernanda Martins Gazoni, Marise Lazaretti-Castro, Maysa Seabra Cendoroglo, John P Bilezikian, Maria Stella Figueiredo, Fania Cristina Dos Santos
{"title":"血液中的α-Klotho和FGF-23浓度与老年人的骨质密度没有相关性。","authors":"Karina Moura Sawada, Niele Silva de Moraes, Lara Miguel Quirino Araújo, Fernanda Martins Gazoni, Marise Lazaretti-Castro, Maysa Seabra Cendoroglo, John P Bilezikian, Maria Stella Figueiredo, Fania Cristina Dos Santos","doi":"10.31744/einstein_journal/2024AO0412","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.</p><p><strong>Methods: </strong>A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis.</p><p><strong>Results: </strong>The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.</p><p><strong>Conclusion: </strong>No substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461005/pdf/","citationCount":"0","resultStr":"{\"title\":\"Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals.\",\"authors\":\"Karina Moura Sawada, Niele Silva de Moraes, Lara Miguel Quirino Araújo, Fernanda Martins Gazoni, Marise Lazaretti-Castro, Maysa Seabra Cendoroglo, John P Bilezikian, Maria Stella Figueiredo, Fania Cristina Dos Santos\",\"doi\":\"10.31744/einstein_journal/2024AO0412\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.</p><p><strong>Methods: </strong>A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis.</p><p><strong>Results: </strong>The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.</p><p><strong>Conclusion: </strong>No substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.</p>\",\"PeriodicalId\":47359,\"journal\":{\"name\":\"Einstein-Sao Paulo\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461005/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Einstein-Sao Paulo\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31744/einstein_journal/2024AO0412\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Einstein-Sao Paulo","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31744/einstein_journal/2024AO0412","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals.
Objective: To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.
Methods: A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis.
Results: The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.
Conclusion: No substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.
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