{"title":"关于 \"胰岛α细胞内 Gs 信号传导促进胰高血糖素释放 \"的评论","authors":"Tadahiro Kitamura","doi":"10.1111/jdi.14317","DOIUrl":null,"url":null,"abstract":"<p><p>The Gs receptor in pancreatic α cells promotes glucagon transcription and secretion via increasing cAMP. The Gi receptor in pancreatic α cells suppresses glucagon secretion via decreasing cAMP. The Gq receptor in pancreatic α cells promotes glucagon secretion via releasing Ca<sup>++</sup> from ER to cytoplasm.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Commentary on \\\"Intra-islet α-cell Gs signaling promotes glucagon release\\\".\",\"authors\":\"Tadahiro Kitamura\",\"doi\":\"10.1111/jdi.14317\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Gs receptor in pancreatic α cells promotes glucagon transcription and secretion via increasing cAMP. The Gi receptor in pancreatic α cells suppresses glucagon secretion via decreasing cAMP. The Gq receptor in pancreatic α cells promotes glucagon secretion via releasing Ca<sup>++</sup> from ER to cytoplasm.</p>\",\"PeriodicalId\":190,\"journal\":{\"name\":\"Journal of Diabetes Investigation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Diabetes Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/jdi.14317\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jdi.14317","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
胰腺α细胞中的Gs受体通过增加cAMP促进胰高血糖素的转录和分泌。胰腺α细胞中的 Gi 受体通过降低 cAMP 抑制胰高血糖素的分泌。胰腺α细胞中的 Gq 受体通过从 ER 向细胞质释放 Ca++ 来促进胰高血糖素的分泌。
Commentary on "Intra-islet α-cell Gs signaling promotes glucagon release".
The Gs receptor in pancreatic α cells promotes glucagon transcription and secretion via increasing cAMP. The Gi receptor in pancreatic α cells suppresses glucagon secretion via decreasing cAMP. The Gq receptor in pancreatic α cells promotes glucagon secretion via releasing Ca++ from ER to cytoplasm.
期刊介绍：
Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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