6,2',4'-三甲氧基黄酮对减轻大鼠再灌注后脑缺血再灌注损伤无效

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-10-01 Epub Date: 2024-09-30 DOI:10.1177/02841851241275278
Chul-Woong Woo, Monica Young Choi, Hwon Heo, Yeon Ji Chae, Yu Sub Sung, Yoonseok Choi, Dong Cheol Woo
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引用次数: 0

摘要

背景:药物抑制缺血后芳基烃受体(AhR)的激活可减轻脑缺血再灌注损伤:目的:探讨再灌注后给予AhR拮抗剂是否也能有效减轻脑缺血再灌注损伤:将 24 只 Sprague-Dawley 大鼠分为假手术组(无 IR)、对照组(IR)和 6,2',4'-三甲氧基黄酮(TMF)组(IR + TMF 给药),每组 10 只。大脑中动脉闭塞 60 分钟后再灌注,诱发脑 IR 损伤。TMF(5 毫克/千克)作为 AhR 拮抗剂,在再灌注后立即腹腔注射。通过磁共振成像(MRI)和神经行为评估观察基线、缺血后立即和缺血后3天的脑IR损伤:在 MRI 上,TMF 组的相对表观弥散系数(ADC)、T2 和分数各向异性(FA)值、中线移位值和梗死体积均无明显差异。在神经行为功能方面,握力、对侧前肢的使用、触摸时间和从前爪取下胶带的时间等因素在对照组和TMF组之间也没有显著差异:本研究表明,再灌注后的 AhR 治疗对减轻大鼠脑 IR 损伤无明显作用。
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Ineffectiveness of 6,2',4'-trimethoxyflavone in mitigating cerebral ischemia/reperfusion injury after post-reperfusion administration in rats.

Background: Pharmacological inhibition of aryl hydrocarbon receptor (AhR) activation after ischemia alleviates cerebral ischemia/reperfusion (IR) injury.

Purpose: To investigate whether AhR antagonist administration after reperfusion was also effective in attenuating cerebral IR injury.

Material and methods: A total of 24 Sprague-Dawley rats were divided into the sham-operated group (no IR), control group (IR), and 6,2',4'-trimethoxyflavone (TMF) group (IR + TMF administration), with 10 rats assigned to each group. Cerebral IR injury was induced by 60 min of middle cerebral artery occlusion followed by reperfusion. TMF (5 mg/kg) was used as the AhR antagonist and was administered intraperitoneally immediately after reperfusion. Cerebral IR injury was observed using magnetic resonance imaging (MRI) and neurobehavioral assessments at baseline, immediately after ischemia, and at 3 days after ischemia.

Results: On MRI, the TMF group showed no significant differences in relative apparent diffusion coefficient (ADC), T2, and fractional anisotropy (FA) values; midline shift value; and infarct volume. In terms of neurobehavioral function, factors such as grip strength, contralateral forelimb use, time to touch, and time to remove adhesive tape from the forepaw, were also not significantly different between the control and TMF groups.

Conclusion: This study demonstrated that AhR treatment after reperfusion had no noticeable effect on reducing cerebral IR injury in rats.

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来源期刊
Acta radiologica
Acta radiologica 医学-核医学
CiteScore
2.70
自引率
0.00%
发文量
170
审稿时长
3-8 weeks
期刊介绍: Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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