瘦孕妇和肥胖孕妇胎盘和白色脂肪组织中 ACE 和 ACE2 的表达水平

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biomarkers Pub Date : 2024-11-01 Epub Date: 2024-10-23 DOI:10.1080/1354750X.2024.2411346

Orcione Ferreira Guimarães Júnior, Gabriel Ledo Pereira de Oliveira, Deborah de Farias Lelis, Thaís de Oliveira Faria Baldo, Marcelo Perim Baldo, Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade

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摘要

背景：本研究评估了瘦和肥胖妇女胎盘和白色脂肪组织中 ACE 和 ACE2 的表达，并将其水平与人体测量、临床和实验室参数以及炎症细胞组织计数相关联：对 49 名孕妇及其新生儿进行了横断面分析研究。胎盘和脂肪组织样本用于通过 qRT-PCR 测量 ACE 和 ACE2 的 mRNA 表达。炎症细胞计数通过传统显微镜进行：结果：在肥胖妇女的胎盘和脂肪组织中观察到 ACE 表达增加，ACE2 减少。ACE2水平与孕前体重指数和总胆固醇呈负相关：结论：母体肥胖可调节胎盘和白色脂肪组织中RAS成分的表达，ACE2与孕前体重指数和总胆固醇相关。

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Expression levels of ACE and ACE2 in the placenta and white adipose tissue of lean and obese pregnant women.

Background: This study evaluated the expression of ACE and ACE2 in the placenta and white adipose tissue in lean and obese women, and correlated their levels with anthropometric, clinical, and laboratory parameters, and tissue count of inflammatory cells.

Methods: A cross-sectional analytical study was performed with 49 pregnant women and their respective newborns. Samples of placenta and adipose tissue were used for measuring mRNA expression for ACE and ACE2 through qRT-PCR. Inflammatory cell counting was performed through conventional microscopy.

Results: An increase in ACE expression and a decrease in ACE2 were observed in the placenta and adipose tissue of women with obesity. ACE2 levels showed a negative correlation with pre-pregnancy BMI and total cholesterol.

Conclusion: Maternal obesity can modulate the expression of RAS components in the placenta and white adipose tissue, with ACE2 correlated with pre-pregnancy BMI and total cholesterol.

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.