Orcione Ferreira Guimarães Júnior, Gabriel Ledo Pereira de Oliveira, Deborah de Farias Lelis, Thaís de Oliveira Faria Baldo, Marcelo Perim Baldo, Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade
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Expression levels of ACE and ACE2 in the placenta and white adipose tissue of lean and obese pregnant women.
Background: This study evaluated the expression of ACE and ACE2 in the placenta and white adipose tissue in lean and obese women, and correlated their levels with anthropometric, clinical, and laboratory parameters, and tissue count of inflammatory cells.
Methods: A cross-sectional analytical study was performed with 49 pregnant women and their respective newborns. Samples of placenta and adipose tissue were used for measuring mRNA expression for ACE and ACE2 through qRT-PCR. Inflammatory cell counting was performed through conventional microscopy.
Results: An increase in ACE expression and a decrease in ACE2 were observed in the placenta and adipose tissue of women with obesity. ACE2 levels showed a negative correlation with pre-pregnancy BMI and total cholesterol.
Conclusion: Maternal obesity can modulate the expression of RAS components in the placenta and white adipose tissue, with ACE2 correlated with pre-pregnancy BMI and total cholesterol.
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