Negin Namavari, Mohammad Jokar, Arnoosh Ghodsian, Hossein Kargar Jahromi, Vahid Rahmanian
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The search aimed to identify studies exploring the association between menopause and rheumatoid arthritis.</p><p><strong>Results: </strong>Our analysis revealed that post-menopausal women had a higher risk of developing rheumatoid arthritis compared to pre-menopausal women, with an estimated odds ratio of 1.35 (95% CI: 1.04-1.67). Additionally, women who experienced early menopause (defined as onset before age 45) showed significantly higher odds of developing RA, with an odds ratio of 2.97 (95% CI: 1.73-4.22).</p><p><strong>Conclusion: </strong>These findings highlight the importance of considering menopausal status when assessing the risk of RA development in women. The results suggest that post-menopausal women, particularly those who experience early menopause, may be at higher risk for developing RA. 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引用次数: 0
摘要
背景:类风湿性关节炎(RA)是一种主要影响关节的慢性炎症。女性的风湿性关节炎发病率较高,加上性激素对免疫功能的已知影响,促使研究人员调查更年期状态与风湿性关节炎的风险、严重程度或进展之间的潜在关系。本系统综述和荟萃分析旨在确定更年期与类风湿关节炎之间的关系:2023 年,我们对多个数据库进行了全面检索,包括 Google Scholar、Scopus、PubMed/MEDLINE、Science Direct、Web of Science、EMBASE、Springer 和 ProQuest。搜索的目的是找出探讨更年期与类风湿性关节炎之间关系的研究:我们的分析表明,与绝经前妇女相比,绝经后妇女患类风湿性关节炎的风险更高,估计的几率比为 1.35(95% CI:1.04-1.67)。此外,更年期提前(定义为 45 岁之前发病)的女性患 RA 的几率明显更高,几率比为 2.97(95% CI:1.73-4.22):这些发现强调了在评估女性罹患 RA 的风险时考虑绝经状态的重要性。结果表明,绝经后的女性,尤其是绝经较早的女性,患 RA 的风险可能较高。在这一领域的进一步研究可为潜在的预防措施和针对高危人群的干预措施提供有价值的见解。
Menopausal state and rheumatoid arthritis: a systematic review and meta-analysis.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition primarily affecting the joints. The higher prevalence of RA among females, combined with the known effects of sex hormones on immune function, has led researchers to investigate the potential relationship between menopausal status and the risk, severity, or progression of RA. This systematic review and meta-analysis aimed to determine the association between menopause and rheumatoid arthritis.
Methods: In 2023, we conducted a comprehensive search across multiple databases, including Google Scholar, Scopus, PubMed/MEDLINE, Science Direct, Web of Science, EMBASE, Springer, and ProQuest. The search aimed to identify studies exploring the association between menopause and rheumatoid arthritis.
Results: Our analysis revealed that post-menopausal women had a higher risk of developing rheumatoid arthritis compared to pre-menopausal women, with an estimated odds ratio of 1.35 (95% CI: 1.04-1.67). Additionally, women who experienced early menopause (defined as onset before age 45) showed significantly higher odds of developing RA, with an odds ratio of 2.97 (95% CI: 1.73-4.22).
Conclusion: These findings highlight the importance of considering menopausal status when assessing the risk of RA development in women. The results suggest that post-menopausal women, particularly those who experience early menopause, may be at higher risk for developing RA. Further research in this area could provide valuable insights into potential preventive measures and targeted interventions for high-risk individuals.