多囊卵巢综合征妇女的高雄激素和人体测量参数。

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM BMC Endocrine Disorders Pub Date : 2024-09-27 DOI:10.1186/s12902-024-01733-y
Asieh Mansour, Maryam Noori, Monir Sadat Hakemi, Ziba Haghgooyan, Mohammad Reza Mohajeri-Tehrani, Maryam Mirahmad, Sayed Mahmoud Sajjadi-Jazi
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引用次数: 0

摘要

目的:多囊卵巢综合征(PCOS)的主要特征之一是脂肪组织增加,这会导致激素紊乱。在本研究中,我们旨在调查哪种肥胖指标能更好地与多囊卵巢综合征妇女的激素紊乱相关联:在这项横断面分析中,根据鹿特丹标准纳入了患有多囊卵巢综合症的女性。对空腹血液样本进行了生化、代谢和激素参数分析。人体测量指标包括身体成分指数(通过生物电阻抗分析[BIA]评估)、腰围、体重指数(BMI)和腰围身高比(WHtR)。线性回归模型用于评估人体测量指数与荷尔蒙失衡之间的关系,并对年龄、体质状况和稳态模型评估-估计胰岛素抵抗(HOMA-IR)进行了调整。利用受体操作特征曲线(ROC)来确定各种人体测量指标在识别高雄激素症方面的敏感性、特异性和最佳临界点:共纳入了 129 名多囊卵巢综合征女性,中位(四分位间[IQR])年龄为 32.0(23.0-32.0)岁,中位体重指数为 26.3(23.00-29.70)kg/m2。在调整后的线性回归模型中,BMI(β = 0.053,P 结论:WHtR 与高胆固醇血症有关:与其他人体测量指标相比,WHtR 与多囊卵巢综合征的高雄激素相关性更好。
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Hyperandrogenism and anthropometric parameters in women with polycystic ovary syndrome.

Objective: One of the main features of polycystic ovary syndrome (PCOS) is increased adipose tissue, which can result in hormonal disturbances. In the present study, we aimed to investigate which indicator of obesity could better associate with hormonal disturbances in PCOS women.

Methods: In this cross-sectional analysis, women with PCOS were included according to the Rotterdam criteria. Fasting blood samples were analyzed for biochemical, metabolic, and hormonal parameters. Anthropometric measures comprised body composition indices (assessed by bioelectric impedance analysis [BIA]), waist circumference, body mass index (BMI), and waist-to-height ratio (WHtR). Linear regression modeling was used to assess the association between anthropometric indices and hormonal imbalance, adjusted for age, mensuration status, and the homeostasis model assessment-estimated insulin resistance (HOMA-IR). Receiver operating characteristics (ROC) curves were utilized to ascertain the sensitivity, specificity, and optimal cut-off points of various anthropometric indices in identifying hyperandrogenism.

Results: A total of 129 PCOS women with a median (interquartile range [IQR]) age of 32.0 (23.0-32.0) years and a median BMI of 26.3 (23.00-29.70) kg/m2 were enrolled. In the adjusted linear regression model, BMI (β = 0.053, P < 0.001), waist circumference (β = 0.021, P = 0.001), WHtR (β = 3.325, P = 0.002), total fat mass (β = 0.021, P = 0.002), trunk fat mass (β = 0.038, P = 0.006), and leg fat mass (β = 0.045, P = 0.004) were positively associated with free androgen index (FAI). In addition, BMI (β=-0.017, P = 0.003), waist circumference (β=-0.008, P = 0.002), WHtR (β=-1.167, P = 0.004), total fat mass (β=-0.008, P=0.003), trunk fat mass (β=-0.017, P=0.001), and leg fat mass (β=-0.018, P=0.004) were negatively associated with the serum level of sex hormone binding globulin (SHBG). WHtR showed the greatest area under the curve (AUC) value (AUC = 0.676, P = 0.001) for identifying hyperandrogenism (FAI ≥ 4.97 or total testosterone ≥ 0.7 ng/mL) in PCOS women with corresponding sensitivity of 87.30% and specificity of 39.70%.

Conclusions: WHtR is related to hyperandrogenism in PCOS better than other anthropometric measures.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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