Jannatul Nayeem, M M Towhidul Islam, Farzana Deeba, Shahjada Selim, Liaquat Ali, Yearul Kabir
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引用次数: 0
摘要
胰岛素抵抗(IR)是多囊卵巢综合征(PCOS)的一个公认的协变量,其负担和风险因素在不同人群中各不相同。胰岛素分泌缺陷(ISD)与多囊卵巢综合征的关系还不太清楚。本病例对照研究对患有多囊卵巢综合症的年轻成人至中年早期、体重正常至肥胖的班加罗尔妇女进行了研究,探讨了 IR 和 ISD 的存在及其协变量。研究有目的性地招募了 158 名多囊卵巢综合症女性(年龄 23(15-34)岁,中位数(范围))和 126 名非多囊卵巢综合症女性(24(19-34)岁),她们都是根据 2003 年修订的鹿特丹标准诊断出的多囊卵巢综合症患者。激素采用 CLIA 方法进行测量,下腹部超声波检查由受过培训的人员进行。以非多囊卵巢综合征组的 HOMA-IR 第 75 百分位值(2.4)和 HOMA%B 第 75 百分位值(143)为临界值,通过稳态模型评估 IR 和 ISD。高雄激素症(HA)通过计算空腹雄激素指数(FAI)来衡量。52% 的多囊卵巢综合症妇女和 28% 的非多囊卵巢综合症妇女的 HOMA-IR 偏高。体重指数(BMI)和 HA 是 IR 的独立相关协变量(p
Insulin resistance and insulin secretory defect among Bangalee PCOS women: a case-control study.
Insulin resistance (IR) is a well-recognized covariate of Polycystic Ovarian Syndrome (PCOS) with varying burden and risk factors among populations. The relationship of insulin secretory defect or ISD with PCOS is less understood. The presence of IR and ISD as well as their covariates have been explored in the present case-control study among young adult to early middle-aged, normal weight to obese, Bangalee women with PCOS. A number of 158 PCOS [age 23 (15-34) years, Median (Range)] and 126 Non-PCOS [24 (19-34) years] females were recruited purposively with PCOS diagnosed following Modified Rotterdam Criteria 2003. Hormones were measured by CLIA method and lower abdominal ultrasonography was done by trained personnel. IR and ISD were assessed by homeostasis model assessment with 75th percentile values of HOMA-IR (2.4) and HOMA%B (143) in Non-PCOS group considered as the cut-off values. Hyperandrogenism (HA) was measured by calculating Fasting Androgen Index (FAI). HOMA-IR was high among 52% of PCOS and 28% of Non-PCOS women. Body Mass Index (BMI) and HA were independently associated covariates of IR (p < 0.001). HOMA%B was compromised among 48% of PCOS subjects and the deficiency showed independent association (p < 0.001) with 2 h glycemia on OGTT in Non-PCOS and HA in PCOS groups. The data suggest insulin resistance as a major risk factor for PCOS among Bangalee women with obesity and hyperandrogenemia as its major covariates. The findings also indicate that presence of impaired insulin secretion is a major determinant of hyperglycemia and, consequently, of higher T2DM risk among young women in this population.
期刊介绍:
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.