儿科炎症性肠病血栓栓塞事件的发生率和风险因素：一项基于法国人口的研究。

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Digestive and Liver Disease Pub Date : 2024-09-24 DOI:10.1016/j.dld.2024.09.005

Nicolas Richard, Ariane Leroyer, Delphine Ley, Claire Dupont, Valérie Bertrand, Pauline Wils, Corine Gower-Rousseau, Dominique Turck, Nathalie Guillon, Hélène Sarter, Guillaume Savoye, Mathurin Fumery

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引用次数: 0

摘要

导言：炎症性肠病（IBD）患者发生血栓栓塞事件（TE）的风险较高。在小儿IBD患者中，需要更多关于静脉（VTE）和动脉事件（ATE）发生率和风险因素的数据，以指导血栓预防：方法：对1988年至2011年间在前瞻性EPIMAD人群登记中确诊为克罗恩病（CD）或溃疡性结肠炎（UC）的所有年龄≤16岁的患者进行随访，直至2013年。随访期间发生的所有TE均被纳入：结果：共纳入 1,344 名患者：结果：共纳入 1,344 名患者：1,007 名 CD 患者和 337 名 UC 患者，中位诊断年龄为 14.3 岁。中位随访 8.3 年后，2 例（0.15%）ATE 和 15 例（1.1%）VTE 发生，中位年龄为 20.4 岁。血栓栓塞事件的总体发病率为每千人年 1.32 例。活动期（HR=8.4，p = 0.0002）、术后 3 个月（HR=16.4，p = 0.0002）和住院期（HR=21.7，p < 0.0001）与 VTE 风险增加有关。使用5-氨基水杨酸盐治疗的患者VTE发生率较低（HR=0.1，P=0.002）：结论：在这一人群中，TE 的风险较低。VTE与活动性疾病、手术和住院密切相关。

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Incidence and risk factors for thromboembolic events in pediatric-onset inflammatory bowel disease: A French population-based study.

Introduction: Patients with inflammatory bowel disease (IBD) are at higher risk of thromboembolic events (TE). In pediatric-onset IBD, more data on incidence and risk factors of venous (VTE) and arterial events (ATE) at the population level are needed to guide thromboprophylaxis.

Methods: All patients aged ≤ 16 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) between 1988 and 2011 in the prospective EPIMAD population-based registry were followed until 2013. Every TE occurring during the follow-up period was included.

Results: A total of 1,344 patients were included: 1,007 with CD and 337 with UC, and a median diagnosis age of 14.3 years. After a median follow-up of 8.3 years, 2 (0.15 %) ATE and 15 (1.1 %) VTE occurred at median age of 20.4 years. The global incidence rate of thromboembolic events was 1.32 per 1000 person-years. Periods of active disease (HR=8.4, p = 0.0002), the 3-month-period following surgery (HR=16.4, p = 0.0002) and hospitalization (HR=21.7, p < 0.0001) were found to be associated with an increased risk of VTE. A lower rate of VTE was found in patients treated with 5-aminosalicylates (HR=0.1, p = 0.002).

Conclusion: The risk of TE was low in this population. VTE were strongly associated with active disease, surgery and hospitalization.

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.