急诊中与淀粉样蛋白相关的成像异常。

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Emergency Radiology Pub Date : 2024-09-27 DOI:10.1007/s10140-024-02286-2

Jan Czerminski, Supriya Khatri, Balaji Rao

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引用次数: 0

摘要

自 2021 年美国食品及药物管理局（FDA）批准第一种治疗阿尔茨海默病（AD）的单克隆抗体（MAB）疗法以来，治疗方法已从症状控制发展到针对并减少淀粉样蛋白 β 斑块负担。虽然这些疗法带来了改变病程的希望，但也伴随着风险，如淀粉样蛋白相关成像异常（ARIA），包括ARIA-E（水肿和渗出）和ARIA-H（出血）。本报告详细介绍了一例接受多那尼单抗治疗的 64 岁女性病例，她出现了严重的 ARIA，其特征是大面积血管源性水肿和多处微出血。随着 MABs 的使用越来越多，急诊放射科医生有必要提高意识和专业知识，以有效识别 ARIA 的发现，确保为接受这些新型疗法的患者提供及时、适当的治疗。

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Amyloid related imaging abnormalities in the emergency setting.

Since the 2021 FDA approval of the first monoclonal antibody (MAB) therapy for Alzheimer's disease (AD), treatment has progressed from symptom management to targeting and reducing amyloid β plaque burden. While these therapies offer hope of altering the disease course, they come with risks, such as amyloid-related imaging abnormalities (ARIA), which include ARIA-E (edema and effusion) and ARIA-H (hemorrhage). This report details the case of a 64-year-old woman undergoing donanemab treatment who developed severe ARIA, characterized by extensive vasogenic edema and multiple microhemorrhages. The increasing use of MABs necessitates heightened awareness and expertise among emergency radiologists to identify findings of ARIA effectively, ensuring timely and appropriate care for patients undergoing these novel therapies.

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来源期刊

Emergency Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

4.50%

发文量

期刊介绍： To advance and improve the radiologic aspects of emergency careTo establish Emergency Radiology as an area of special interest in the field of diagnostic imagingTo improve methods of education in Emergency RadiologyTo provide, through formal meetings, a mechanism for presentation of scientific papers on various aspects of Emergency Radiology and continuing educationTo promote research in Emergency Radiology by clinical and basic science investigators, including residents and other traineesTo act as the resource body on Emergency Radiology for those interested in emergency patient care Members of the American Society of Emergency Radiology (ASER) receive the Emergency Radiology journal as a benefit of membership!