健康人进行动态上肢阻力运动时的神经血管耦合。

IF 2.6 4区 医学 Q2 PHYSIOLOGY Experimental Physiology Pub Date : 2024-09-25 DOI:10.1113/EP091970
Stephanie Korad, Toby Mündel, Blake G Perry
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引用次数: 0

摘要

在单侧静态和有节奏的手握运动中,运动肢体对侧的大脑中动脉血流速度(MCAv)会增加。然而,在动态阻力运动(RE)产生的灌注压力波动背景下,这种神经血管耦合介导的对侧 MCAv 增加是否明显尚不清楚。我们研究了 30 名健康人(女性 = 16,平均 ± SD:年龄,26 ± 6 岁;身高,175 ± 10 厘米;体重,74 ± 15 千克;体重指数,24 ± 5 千克 m-2)对单侧动态阻力运动的脑血流动力学反应。参与者以预测单次最大次数(7 ± 3 千克)的 60% 完成四组 10 次有节奏重复(每分钟重复 15 次)的单侧二头肌卷曲运动。全程测量心跳血压、双侧 MCAv 和潮气末二氧化碳。单因素方差分析用于分析心血管变量,双因素方差分析用于分析脑血管依赖变量(边×组,2×5)。还进行了线性混合模型分析,以研究潮气末二氧化碳和平均动脉血压对 MCAv 的影响。与基线相比,运动内平均动脉血压升高(P 0.787)。线性混合模型显示,潮气末二氧化碳对 MCAv 的影响最大(估计值 = 1.019,t = 8.490,P
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Neurovascular coupling during dynamic upper body resistance exercise in healthy individuals.

During unilateral static and rhythmic handgrip exercise, middle cerebral artery blood velocity (MCAv) increases in the contralateral side to the exercising limb. However, whether this neurovascular coupling-mediated increase in contralateral MCAv is apparent against a background of fluctuating perfusion pressure produced by dynamic resistance exercise (RE) is unclear. We examined the cerebral haemodynamic response to unilateral dynamic RE in 30 healthy individuals (female = 16, mean ± SD: age, 26 ± 6 years; height, 175 ± 10 cm; weight, 74 ± 15 kg; body mass index, 24 ± 5 kg m-2). Participants completed four sets of 10 paced repetitions (15 repetitions min-1) of unilateral bicep curl exercise at 60% of the predicted one-repetition maximum (7 ± 3 kg). Beat-to-beat blood pressure, bilateral MCAv and end-tidal carbon dioxide were measured throughout. One-way ANOVA was used to analyse cardiovascular variables and two-way ANOVA to analyse dependent cerebrovascular variables (side × sets, 2 × 5). A linear mixed model analysis was also performed to investigate the effects of end-tidal carbon dioxide and mean arterial blood pressure on MCAv. In comparison to baseline, within-exercise mean arterial blood pressure increased (P < 0.001) across the sets, whereas bilateral MCAv decreased (P < 0.001). However, no significant interaction effect was observed for any dependent variables (all P > 0.787). The linear mixed model revealed that end-tidal carbon dioxide had the greatest effect on MCAv (estimate = 1.019, t = 8.490, P < 0.001). No differences were seen in contralateral and ipsilateral MCAv during dynamic RE, suggesting that neurovascular coupling contributions during dynamic RE might be masked by other regulators, such as blood pressure.

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来源期刊
Experimental Physiology
Experimental Physiology 医学-生理学
CiteScore
5.10
自引率
3.70%
发文量
262
审稿时长
1 months
期刊介绍: Experimental Physiology publishes research papers that report novel insights into homeostatic and adaptive responses in health, as well as those that further our understanding of pathophysiological mechanisms in disease. We encourage papers that embrace the journal’s orientation of translation and integration, including studies of the adaptive responses to exercise, acute and chronic environmental stressors, growth and aging, and diseases where integrative homeostatic mechanisms play a key role in the response to and evolution of the disease process. Examples of such diseases include hypertension, heart failure, hypoxic lung disease, endocrine and neurological disorders. We are also keen to publish research that has a translational aspect or clinical application. Comparative physiology work that can be applied to aid the understanding human physiology is also encouraged. Manuscripts that report the use of bioinformatic, genomic, molecular, proteomic and cellular techniques to provide novel insights into integrative physiological and pathophysiological mechanisms are welcomed.
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