Amanda Cardoso, Laiana Azevedo Quagliato, Natia Horato, Pablo Eduardo Pereira Dutra, Antonio Egidio Nardi
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引用次数: 0
摘要
导言:心肌梗死后出现抑郁与全因死亡率、心血管死亡率和心血管事件风险增加 2 到 2.5 倍有关。本研究的目的是通过广泛检索文献,研究重度抑郁症是否与中年心肌缺血患者精神状况恶化有关:方法:我们在 PubMed、Embase、PsycINFO 和 Web of Science 数据库中广泛检索了有关重度抑郁症与心肌缺血之间关系的研究。研究纳入了针对伴有抑郁症状的心肌缺血中年患者的随机临床试验:本系统综述收录的 14 篇文章并未证实心肌缺血和抑郁症与中年患者较差的精神状况之间存在关联。然而,在心肌梗塞后患有抑郁症的患者中观察到了更差的心血管预后:本研究结果表明,重度抑郁症会增加急性心肌梗死后患者的心血管风险,这可能是因为炎症标志物的增加更为明显:本系统综述已在国际系统综述前瞻性注册中心(PROSPERO)注册,注册号为 CRD: 511650。
Linking head and heart health: the association between psychiatric outcomes for patients with major depressive disorder and myocardial ischemia - a systematic review.
Introduction: The development of depression after myocardial infarction is associated with a 2- to 2.5-fold increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular events. The objective of this study was to investigate, through a broad search of the literature, whether major depression is associated with worse psychiatric outcomes in middle-aged patients with myocardial ischemia.
Methods: An extensive search for studies on the association between major depression and myocardial ischemia was conducted in the PubMed, Embase, PsycINFO, and Web of Science databases. Randomized clinical trials of middle-aged patients with myocardial ischemia and concomitant depressive symptoms were included.
Results: The 14 articles included in this systematic review did not confirm an association between myocardial ischemia and depression with worse psychiatric outcomes in middle-aged patients. However, worse cardiovascular outcomes have been observed in patients with depression after myocardial infarction.
Conclusions: The findings of this study suggest that major depression increases cardiovascular risk in patients after acute myocardial infarction, possibly because of a more pronounced increase in inflammatory markers.
Registration: This systematic review was registered in the International Prospective Registry of Systematic Reviews (PROSPERO) under the number CRD: 511650.
期刊介绍:
Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.