刺五加种子中的倍半萜及其抗神经发炎活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-09-24 DOI:10.1016/j.fitote.2024.106239

Zheyang Wei , Bo Li , Ablajan Turak , Haji Akber Aisa

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引用次数: 0

摘要

从 Cichorium glandulosum 的种子中分离出了三种以前未曾描述过的倍半萜内酯以及三种已知的倍半萜内酯。通过分析光谱数据，阐明了它们的结构。在 BV-2 细胞中测试了分离出的化合物对 LPS 诱导的神经炎症的神经保护作用。山豆根碱（5）对 LPS 诱导的 BV-2 细胞 NO 生成具有抑制作用，IC50 为 0.89 ± 0.12 μM。化合物 5 的作用机制与激活 NF-κB、MAPK 和 cGAS/STING 通路有关。

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Sesquiterpenes from the seeds of Cichorium glandulosum and their anti- neuroinflammation activities

Three previously undescribed sesquiterpenes, along with three known ones were isolated from the seeds of Cichorium glandulosum. The structures of them were elucidated by the analysis of spectroscopic data. The isolated compounds were tested for their neuroprotective effects against LPS-induced neuroinflammation in BV-2 cells. Santamarine (5) exhibited inhibitory activity on LPS-induced NO production in BV-2 cells with IC₅₀ of 0.89 ± 0.12 μM. The mechanism of the compound 5 was related to activating the NF-κB, MAPK and cGAS/STING pathways.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.