Ping Hai , Haiyan Jia , Zhiqiang Luo , Huixia Fan , Yunqing He , Xianyan Li , Peng Lin , Qin Zhang , Yuan Gao , Jian Yang
{"title":"Arnebia euchroma 中具有抗三阴性乳腺癌和抗菌活性的 Meroterpenoids。","authors":"Ping Hai , Haiyan Jia , Zhiqiang Luo , Huixia Fan , Yunqing He , Xianyan Li , Peng Lin , Qin Zhang , Yuan Gao , Jian Yang","doi":"10.1016/j.fitote.2024.106234","DOIUrl":null,"url":null,"abstract":"<div><div>Two new meroterpenoids, arneuchrols A and B (<strong>1</strong> and <strong>2</strong>), together with twelve known analogs (<strong>3</strong>–<strong>14</strong>) were isolated from the root of <em>Arnebia euchroma</em>. The structures of <strong>1</strong> and <strong>2</strong> including their absolute configurations were elucidated by NMR, HRESIMS, and DFT calculation of their NMR and ECD data. The structure of pseudoshikonin I, firstly isolated from <em>Lithospermi radix</em> was revised as shikonofuran E (<strong>4</strong>). Anti-triple negative breast cancer (anti-TNBC) and antimicrobial activities of the isolated compounds were tested. Compounds <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, <strong>7</strong>, <strong>9</strong>, <strong>10</strong>, and <strong>13</strong> exhibited potent inhibitory activity against TNBC (MDA-MB-231 cells) with IC<sub>50</sub> values in the range of 0.18–4.58 μM. Compound <strong>10</strong> displayed antifungal activity against five plant pathogenic fungi with MIC values in the range of 6.25–25 μg/mL. Compound <strong>9</strong> exhibited antibacterial activity against <em>Micrococcus lysodeikticus</em> with MIC value of 12.5 μg/mL.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106234"},"PeriodicalIF":2.5000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Meroterpenoids with anti-triple negative breast cancer and antimicrobial activities from Arnebia euchroma\",\"authors\":\"Ping Hai , Haiyan Jia , Zhiqiang Luo , Huixia Fan , Yunqing He , Xianyan Li , Peng Lin , Qin Zhang , Yuan Gao , Jian Yang\",\"doi\":\"10.1016/j.fitote.2024.106234\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two new meroterpenoids, arneuchrols A and B (<strong>1</strong> and <strong>2</strong>), together with twelve known analogs (<strong>3</strong>–<strong>14</strong>) were isolated from the root of <em>Arnebia euchroma</em>. The structures of <strong>1</strong> and <strong>2</strong> including their absolute configurations were elucidated by NMR, HRESIMS, and DFT calculation of their NMR and ECD data. The structure of pseudoshikonin I, firstly isolated from <em>Lithospermi radix</em> was revised as shikonofuran E (<strong>4</strong>). Anti-triple negative breast cancer (anti-TNBC) and antimicrobial activities of the isolated compounds were tested. Compounds <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, <strong>7</strong>, <strong>9</strong>, <strong>10</strong>, and <strong>13</strong> exhibited potent inhibitory activity against TNBC (MDA-MB-231 cells) with IC<sub>50</sub> values in the range of 0.18–4.58 μM. Compound <strong>10</strong> displayed antifungal activity against five plant pathogenic fungi with MIC values in the range of 6.25–25 μg/mL. Compound <strong>9</strong> exhibited antibacterial activity against <em>Micrococcus lysodeikticus</em> with MIC value of 12.5 μg/mL.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"179 \",\"pages\":\"Article 106234\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004179\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004179","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Meroterpenoids with anti-triple negative breast cancer and antimicrobial activities from Arnebia euchroma
Two new meroterpenoids, arneuchrols A and B (1 and 2), together with twelve known analogs (3–14) were isolated from the root of Arnebia euchroma. The structures of 1 and 2 including their absolute configurations were elucidated by NMR, HRESIMS, and DFT calculation of their NMR and ECD data. The structure of pseudoshikonin I, firstly isolated from Lithospermi radix was revised as shikonofuran E (4). Anti-triple negative breast cancer (anti-TNBC) and antimicrobial activities of the isolated compounds were tested. Compounds 3, 4, 6, 7, 9, 10, and 13 exhibited potent inhibitory activity against TNBC (MDA-MB-231 cells) with IC50 values in the range of 0.18–4.58 μM. Compound 10 displayed antifungal activity against five plant pathogenic fungi with MIC values in the range of 6.25–25 μg/mL. Compound 9 exhibited antibacterial activity against Micrococcus lysodeikticus with MIC value of 12.5 μg/mL.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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