评估姜黄素衍生的碳纳米点对传染病的疗效。

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES Expert Review of Anti-infective Therapy Pub Date : 2024-10-07 DOI:10.1080/14787210.2024.2409401
Mahendra Rai, Avinash P Ingle, Gréta Törős, József Prokisch
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引用次数: 0

摘要

导言:新出现的耐多药微生物的威胁与日俱增,因此需要新的抗菌药物。在这方面,纳米技术可以作为治疗传染性微生物的一种替代方法。姜黄素自古以来就被用作抗菌剂,但由于其水溶性、生物利用度和生物相容性较差,因此存在一定的局限性。姜黄素衍生的碳纳米点是一种新兴的抗菌剂,可以解决这一问题:本综述讨论了姜黄素衍生碳纳米点在抗击各种病原微生物(包括细菌和 SARS-CoV-2 等可怕病毒)方面的应用。此外,还对姜黄素碳纳米点在病原微生物生物标记、作用机制、生物成像和治疗方面的作用进行了严格审查:碳纳米点在抗病原微生物的早期诊断、生物成像、抗菌药物纳米载体和治疗传染病方面发挥着重要作用。姜黄素纳米碳点已证明其具有水溶性、生物可利用性和生物相容性等优点。然而,要了解姜黄素碳纳米点的功效和安全性,还需要进行更深入的研究。未来,姜黄素衍生碳纳米点可用作替代抗菌剂,以对抗微生物感染,包括耐多药微生物。
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Assessing the efficacy of carbon nanodots derived from curcumin on infectious diseases.

Introduction: The threat of new, emerging, and multidrug-resistant microbes is increasing which has created the necessity for new antimicrobials. In this regard, nanotechnology can be an alternative for the treatment of infectious microbes. Curcumin has been used since ancient times as antimicrobials; however, it has limitations due to its less aqueous solubility, bioavailability, and biocompatibility. This problem can be solved by curcumin-derived carbon nanodots, which are emerging antimicrobials of <10 nm size, water-soluble, biocompatible, less toxic, and fluorescent.

Areas covered: The review discusses the application of curcumin-derived carbon nanodots against various pathogenic microbes including bacteria and dreaded viruses like SARS-CoV-2. In addition, the role of curcumin carbon nanodots in biolabelling of pathogenic microbes, mechanism of action, bioimaging, and therapy has been critically examined.

Expert opinion: Carbon nanodots play an important role in combating pathogenic microbes by early diagnosis, bioimaging, nanocarrier for antimicrobial drugs, and therapy of infectious diseases. Curcumin carbon nanodots have already demonstrated their benefits of being water soluble, bioavailable, and biocompatible. However, more thorough research is needed to understand the efficacy and safety of curcumin carbon nanodots. In the future, curcumin-derived carbon nanodots can be used as alternative antimicrobial agents to fight microbial infections including multidrug-resistant microbes.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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