以完全消失率为基础,研究热消融良性甲状腺结节的最佳最大直径。

IF 3 3区 医学 Q2 ONCOLOGY International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI:10.1080/02656736.2024.2408374
Shi-Liang Cao, Wan-Ying Shi, Zhen-Long Zhao, Ying Wei, Na Yu, Jie Wu, Li-Li Peng, Yan Li, Ming-An Yu
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引用次数: 0

摘要

目的:热消融(TA)是治疗甲状腺良性结节(BTN)的一种安全有效的方法。然而,关于热消融治疗甲状腺良性结节的最佳最大直径(MD)尚未达成共识。本研究旨在根据TA术后完全消失率确定TA治疗BTN的最佳最大直径:这项回顾性研究纳入了 2014 年 6 月至 2022 年 1 月期间接受 TA 治疗的 639 例 BTN。总结了TA术后BTN的完全消失率,探讨了相关影响因素,并确定了TA术后BTN的最佳MD:最终随访(中位数:40 个月,范围:24-95 个月)时,总体体积缩小率为 95.4 ± 9.0%,50.5% 的 BTNs(323/639)完全消失。MD 与完全消失呈明显负相关(几率比 0.89,95% 置信区间 0.87-0.92;P 25.0 mm 的并发症发生率更高(6.5% 对 2.4%,P = 0.012):结论:BTN的MD与TA术后完全消失呈负相关;与MD≤25.0毫米相比,MD>25.0毫米表明完全消失的可能性降低。根据完全消失率,25.0 毫米的 MD 是 BTN 进行 TA 的合适阈值。
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Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate.

Objective: Thermal ablation (TA) is a safe and effective treatment for benign thyroid nodules (BTNs). However, there has been no consensus on the optimal maximum diameter (MD) of BTNs for TA. This study aimed to identify the optimal MD of BTNs for TA based on complete disappearance rate after TA.

Materials and methods: This retrospective study included 639 BTNs treated with TA from June 2014 to January 2022. The complete disappearance rate of BTNs after TA was summarized, related influencing factors were explored, and the optimal MD of BTNs for TA was identified.

Results: At the final follow-up (median: 40 months, range: 24-95 months), the overall volume reduction rate was 95.4 ± 9.0%, and 50.5% of the BTNs (323/639) completely disappeared. The MD was significantly negatively correlated with complete disappearance (odds ratio 0.89, 95% confidence interval 0.87-0.92; p < 0.001). Calcification, comet-tail artifacts, multilocular cysts, and composition of BTNs, as well as diabetes were negatively correlated with complete disappearance. Restricted cubic spline indicated that an MD of 25.0 mm was the optimal threshold of BTNs for TA, which was confirmed by subgroup logistic regression analysis. Compared with BTNs with MD ≤ 25.0 mm, those with MD > 25.0 mm had a greater complication rate (6.5% vs. 2.4%, p = 0.012).

Conclusions: The MD of BTNs was negatively correlated with complete disappearance after TA; an MD > 25.0 mm indicated a reduced likelihood of complete disappearance compared with an MD ≤ 25.0 mm. An MD of 25.0 mm is an appropriate threshold of BTNs for TA on the basis of complete disappearance rate.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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