日本 COVID-19 老年病例感染 Omicron 变体的死亡风险:一项基于人群的研究。

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Japanese journal of infectious diseases Pub Date : 2024-09-30 DOI:10.7883/yoken.JJID.2024.071
Hideo Tanaka, Yuki Takahashi, Yoshitaka Koga, Shunichi Takiguchi, Shigeru Ogimoto, Shizuyo Inaba, Hiroyuki Matsuoka, Yuka Miyajima, Takeshi Takagi, Fujiko Irie, Yoshihito Bamba, Fuyo Yoshimi, Tomoyuki Suzuki, Isao Araki, Chika Shirai, Sayuri Matsumoto, Toshiyuki Shibata, Hitomi Nagai, Masaru Kinoshita, Rie Fujita, Tsuyoshi Ogata
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引用次数: 0

摘要

我们评估了 2022 年 1 月至 2023 年 3 月期间在日本 10 个都道府县(1480 万居民)确诊的年龄≥70 岁病例的病死率(CFR),当时奥米克龙变异体在日本占主导地位。我们从遵守《传染病防治法》的公共卫生中心选取了 283,052 名研究对象的病例报告。我们对病例进行了被动随访,直至其隔离期结束、死亡日期或确诊 COVID-19 后 28 天(以先发生者为准)。我们以 2022 年年龄在 70-79 岁、80-89 岁和≥90 岁的日本人口为研究对象,根据 COVID-19 诊断时间分为 16 个亚组,计算了年龄标准化 CFR 及 95% 置信区间 (CI)。总CFR为1.59%(95% CI 1.55-1.64);介于0.67%(95% CI 0.38-0.96,5月23日至6月19日)和2.58%(95% CI 2.36-2.80,1月31日至2月27日)之间。我们观察到年龄标准化 CFR 的三个峰值与日本由 Omicron 驱动的第 6、7 和 8 次 COVID-19 流行波(分别为 2.2%,1 月 31 日-2 月 27 日;1.0%,7 月 18 日-8 月 14 日;1.6%,12 月 26 日-2023 年 1 月 22 日)相平行。年龄≥70 岁的日本人中 Omicron 变体 COVID-19 的基于人口的 CFR 仍为
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Risk of death in old Japanese COVID-19 cases infected with the Omicron variant: a population-based study.

We assessed case fatality rates (CFRs) in cases aged ≥70 years in 10 Japanese prefectures (14.8 million residents) diagnosed between January 2022 and March 2023, when the Omicron variant was dominant in Japan. We selected incident reports on 283,052 study subjects from participating Public Health Centers adhering to the Infectious Diseases Control Law. Cases were passively followed up until the end of their isolation, date of death or 28 days after the COVID-19 diagnosis, whichever occurred first. We calculated age-standardized CFRs with 95% confidence intervals (CI) using the Japanese population aged 70-79, 80-89 and ≥90 in 2022 divided into 16 subgroups according to the period of COVID-19 diagnosis. The total overall CFR was 1.59% (95% CI 1.55-1.64); it ranged between 0.67% (95% CI 0.38-0.96, May 23-June 19) and 2.58% (95% CI 2.36-2.80, January 31-February 27). We observed three peaks of age-standardized CFRs paralleling the 6th, 7th and 8th endemic COVID-19 waves driven by Omicron in Japan (2.2% January 31-February 27, 1.0% July 18-August 14 and 1.6% December 26-January 22, 2023, respectively). Population-based CFRs for Omicron variant COVID-19 in Japanese aged ≥70 years remained <3% throughout the period January 2022-March 2023, including during three large endemic waves in this country.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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