甲基丙烯酸化过程对壳聚糖作为三维打印生物材料成分的实用性的影响》(The Impact of the Methacrylation Process on the Usefulness of Chitosan as a Biaterial Component for 3D Printing)。

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-08-30 DOI:10.3390/jfb15090251
Marta Klak, Katarzyna Kosowska, Milena Czajka, Magdalena Dec, Sylwester Domański, Agnieszka Zakrzewska, Paulina Korycka, Kamila Jankowska, Agnieszka Romanik-Chruścielewska, Michał Wszoła
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引用次数: 0

摘要

壳聚糖是一种非常有前景的组织模型打印材料。众所周知,以甲基丙烯酸酯基团的形式对材料结构进行化学修饰使其在组织模型生物打印中的应用极具吸引力。这项工作的目的是研究含壳聚糖(BCH)及其甲基丙烯酸酯等同物(BCM)的生物材料的特性,以确定它们在三维生物打印技术中的用途差异。研究表明,含有甲基丙烯酸壳聚糖的 BCM 材料的粘度是未甲基丙烯酸化 BCH 材料的三倍。此外,BCM 材料还具有在更大应力范围内的稳定性,以及更好的可打印性、分辨率和纤维稳定性。与 BCH 材料相比,BCM 材料具有更高的机械参数,包括机械强度和杨氏模量。两种材料都非常适合生物打印,但 BCM 具有独特的流变特性和显著的机械阻力。此外,生物测试表明,在生物材料中添加壳聚糖可增加细胞增殖,尤其是在三维打印模型中。此外,以甲基丙烯酸化的形式进行改性可降低三维结构中生物材料的毒性。我们的研究表明,壳聚糖增强型生物材料(特别是经过甲基丙烯酸酯处理的生物材料)适合应用于组织工程,尤其是需要抗高应力的组织,如血管或软骨模型。
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The Impact of the Methacrylation Process on the Usefulness of Chitosan as a Biomaterial Component for 3D Printing.

Chitosan is a very promising material for tissue model printing. It is also known that the introduction of chemical modifications to the structure of the material in the form of methacrylate groups makes it very attractive for application in the bioprinting of tissue models. The aim of this work is to study the characteristics of biomaterials containing chitosan (BCH) and its methacrylated equivalent (BCM) in order to identify differences in their usefulness in 3D bioprinting technology. It has been shown that the BCM material containing methacrylic chitosan is three times more viscous than its non-methacrylated BCH counterpart. Additionally, the BCM material is characterized by stability in a larger range of stresses, as well as better printability, resolution, and fiber stability. The BCM material has higher mechanical parameters, both mechanical strength and Young's modulus, than the BCH material. Both materials are ideal for bioprinting, but BCM has unique rheological properties and significant mechanical resistance. In addition, biological tests have shown that the addition of chitosan to biomaterials increases cell proliferation, particularly in 3D-printed models. Moreover, modification in the form of methacrylation encourages reduced toxicity of the biomaterial in 3D constructs. Our investigation demonstrates the suitability of a chitosan-enhanced biomaterial, specifically methacrylate-treated, for application in tissue engineering, and particularly for tissues requiring resistance to high stress, i.e., vascular or cartilage models.

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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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