美国癌症联合委员会新第九版肛门鳞状细胞癌分期系统的人群水平验证》(A Population-Level Validation of the New 9th Edition of American Joint Commission on Cancer Staging System for Anal Squamous Cell Carcinoma)。
Aos Karim, Alexander Troester, Sarah L Mott, Elliot Arsoniadis, Christine Jensen, Imran Hassan, Pridvi Kandagatla, Paolo Goffredo
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引用次数: 0
摘要
背景和目的:最近对肛门鳞状细胞癌(ASCC)的分期系统进行了修订,降低了部分结节阳性患者的分期,提高了部分肿瘤较大患者的分期。我们的目的是通过基于人群的队列来验证这一分期系统:方法:我们对监测、流行病学和最终结果数据库进行了分析,以确定成年 ASCC 患者。根据美国癌症联合委员会(AJCC)第 8 版和第 9 版系统对患者进行分期。采用卡普兰-梅耶曲线估算生存概率。利用 Cox 回归模型估算分期对总生存期(OS)和癌症特异性生存期(CSS)的影响:结果:共确定了 2117 名患者,并根据 AJCC 的两种分类进行了分期。在24个月时,比较IIB期和IIIA期,第8版显示IIIA期患者的OS(79% vs. 88%)和CSS(84% vs. 91%)均有所改善,而第9版则恢复了OS(IIB 88% vs. IIIA 78%)和CSS(91% vs. 82%)的分级顺序:结论:各疾病分期的 OS HRs 和几乎所有 CSS HRs 的分级增加验证了 AJCC 分类法的更新版。虽然这一变化对 ASCC 的管理可能没有重大影响,但它确实提供了更好的预后。
A Population-Level Validation of the New 9th Edition of the American Joint Commission on Cancer Staging System for Anal Squamous Cell Carcinoma.
Background and objectives: The staging system for anal squamous cell carcinoma (ASCC) was recently revised, downstaging selected node-positive patients and upstaging some with larger tumors. We aimed to validate this staging system using a population-based cohort.
Methods: The Surveillance, Epidemiology, and End Results database was analyzed to identify adult ASCC patients. Patients were staged according to the American Joint Committee on Cancer (AJCC) 8th and 9th edition systems. Survival probabilities were estimated using Kaplan-Meier curves. Cox regression models were utilized to estimate the effect of stage on overall (OS) and cancer-specific survival (CSS).
Results: A total of 2117 patients were identified and staged based on the two AJCC classifications. At 24 months when comparing stage IIB versus stage IIIA, the 8th edition revealed an improved OS (79% vs. 88%) and CSS (84% vs. 91%) for stage IIIA disease, while the 9th edition restored the hierarchical OS (IIB 88% vs. IIIA 78%) and CSS (91% vs. 82%) order.
Conclusions: The hierarchical increase of the OS HRs, and nearly all CSS HRs, across disease stages validated the updated edition of the AJCC classification. Although this change may not have significant implication on the management of ASCC, it does provide better prognostication.
期刊介绍:
The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.