法尼单抗相关视网膜血管炎。

IF 0.5 Q4 OPHTHALMOLOGY Journal of VitreoRetinal Diseases Pub Date : 2024-05-29 eCollection Date: 2024-09-01 DOI:10.1177/24741264241253899
Mohammad Z Siddiqui, Alia Durrani, Bradley T Smith
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引用次数: 0

摘要

目的:报告一例玻璃体内注射法尼单抗-voa 后发生视网膜血管炎的病例。方法:回顾一例病例及其处理。结果一名 77 岁的妇女因新生血管性老年黄斑变性接受了玻璃体内法尼单抗-voa 注射治疗,随后出现无痛性视力下降,只能数手指。检查显示前房有反应,但无眼睑下垂。玻璃体炎伴有大量散在视网膜出血。荧光素血管造影显示充盈延迟,并伴有广泛的血管渗漏,与非闭塞性脉管炎一致。患者立即接受了静脉类固醇治疗,结果病情迅速好转,恢复了 20/40 的基线视力。脉管炎在没有闭塞的情况下得到缓解。结论Faricimab-svoa 可导致严重的血管炎。及时使用静脉类固醇治疗有助于恢复视力。
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Faricimab-Associated Retinal Vasculitis.

Purpose: To report a case of retinal vasculitis after intravitreal faricimab-svoa injection. Methods: A case and its management were reviewed. Results: A 77-year-old woman presented with a painless decrease in visual acuity (VA) to counting fingers after receiving an intravitreal faricimab-svoa injection for neovascular age-related macular degeneration. An examination showed an anterior chamber reaction without hypopyon. Vitritis was present with numerous scattered retinal hemorrhages. Fluorescein angiography showed delayed filling with extensive vascular leakage consistent with nonocclusive vasculitis. The patient was immediately treated with intravenous steroids, resulting in rapid improvement and recovery of her 20/40 baseline VA. The vasculitis resolved without occlusion. Conclusions: Faricimab-svoa can be associated with significant vasculitis. Prompt treatment with intravenous steroids can be beneficial in the recovery of sight.

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