多发性硬化症和癌症:驾驭双重诊断。

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-09-30 DOI:10.1177/13524585241274523
Cassie Nesbitt, Anneke Van Der Walt, Helmut Butzkueven, Bianca Devitt, Vilija G Jokubaitis
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引用次数: 0

摘要

医疗保健方面的突破正在延长多发性硬化症(MS)患者和癌症幸存者的生命,从而使越来越多的人在双重诊断中游刃有余。确定多发性硬化症与癌症风险之间的关系仍具有挑战性,由于年龄、风险暴露、合并症、遗传学以及在研究期间不断引入新的多发性硬化症疾病修饰疗法(DMTs)等因素的影响,目前尚无定论。我们的综述探讨了有关多发性硬化症、癌症风险以及 DMTs 和癌症治疗交叉的现有文献。我们旨在了解癌症幸存者多发性硬化症管理的复杂性,以优化两种疾病的治疗效果。持续的研究和治疗指南的制定对于指导未来的治疗至关重要。神经免疫学和肿瘤学之间的合作至关重要,需要建立数据库,对这些快速发展领域的治疗效果进行回顾性分析,并最终进行前瞻性分析。
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Multiple sclerosis and cancer: Navigating a dual diagnosis.

Healthcare breakthroughs are extending the lives of multiple sclerosis (MS) patients and cancer survivors, creating a growing cohort of individuals navigating a dual diagnosis. Determining the relationship between MS and cancer risk remains challenging, with inconclusive findings confounded by age, risk exposures, comorbidities, genetics and the ongoing introduction of new MS disease-modifying therapies (DMTs) across study periods.This research places significant emphasis on cancer survival, with less attention given to the impact on MS outcomes. Our review explores the existing literature on MS, cancer risk and the intersection of DMTs and cancer treatments. We aim to navigate the complexities of managing MS in cancer survivors to optimise outcomes for both conditions. Continuous research and the formulation of treatment guidelines are essential for guiding future care. Collaboration between neuro-immunology and oncology is crucial, with a need to establish databases for retrospective and ultimately prospective analysis of outcomes in these rapidly evolving fields.

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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
Choroid plexus as a mediator of CNS inflammation in multiple sclerosis. Exploring the relationship between polycystic ovarian syndrome, testosterone, and multiple sclerosis in women: A nationwide cohort study and genome-wide cross-trait analysis. Impact of symptomatic multiple sclerosis therapy on pregnancy outcome. McArdle sign and neck flexion-induced change in central motor conduction in multiple sclerosis. How to avoid missing a diagnosis of neuromyelitis optica spectrum disorder.
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