健康人群脑血管周围空间扩大与血浆渗透压相关:一项纵向研究。

IF 4.7 2区 医学 Q1 NEUROIMAGING NeuroImage Pub Date : 2024-09-26 DOI:10.1016/j.neuroimage.2024.120871
Alexandra Morozova , Filip Španiel , Antonín Škoch , Marek Brabec , Grygoriy Zolotarov , Vladimir Musil , Petr Zach
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引用次数: 0

摘要

扩大的血管周围间隙(EPVS)越来越多地被认为是神经炎症过程和与年龄相关的神经退行性病变的核磁共振成像检测特征。了解健康人的血管周围特征对于将其作为病理变化的参考至关重要。关于年轻健康受试者 EPVS 负荷和半球间分布不对称的数据有限。尽管已知水合对大脑形态计量研究有影响,但血浆渗透压对 EPVS 的影响仍未得到探讨。本研究调查了年龄、颅内总容积(TIV)和血浆渗透压对 EPVS 特征的影响,59 名健康成人在 14.8 个月内(平均 ± 4 个月)接受了两次核磁共振成像和渗透压评估。使用高分辨率自动分割技术在半卵圆中心进行 EPVS 分析,然后使用优化算法提高 EPVS 分割的准确性。统计分析采用线性混合效应模型,结果显示 EPVS 负荷和半球间不对称在个体间存在显著差异。EPVS 容量随年龄、较高的 TIV 和较低的血浆渗透压水平而增加。我们的研究结果为了解健康人群的 EPVS 特征提供了宝贵的见解,为进一步探索与年龄相关的病理变化奠定了基础。
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Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study
Enlarged perivascular spaces (EPVS) are increasingly recognized as an MRI detectable feature of neuroinflammatory processes and age-related neurodegenerative changes. Understanding perivascular characteristics in healthy individuals is crucial for their applicability as a reference for pathological changes. Limited data exists on the EPVS load and interhemispheric asymmetry in distribution among young healthy subjects. Despite the known impact of hydration on brain morphometric studies, blood plasma osmolality's effect on EPVS remains unexplored.
This study investigated the influence of age, total intracranial volume (TIV), and blood plasma osmolality on EPVS characteristics in 59 healthy adults, each undergoing MRI and osmolality assessment twice within 14.8 months (mean ± 4 months). EPVS analysis was conducted in the centrum semiovale using high-resolution automated segmentation, followed by an optimization algorithm to enhance EPVS segmentation accuracy. Linear Mixed Effects model was used for the statistical analysis, which unveiled significant inter-individual variability in EPVS load and inter-hemispheric asymmetry. EPVS volume increased with age, higher TIV and lower blood plasma osmolality levels. Our findings offer valuable insights into EPVS characteristics among the healthy population, establishing a foundation to further explore age-related and pathological changes.
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来源期刊
NeuroImage
NeuroImage 医学-核医学
CiteScore
11.30
自引率
10.50%
发文量
809
审稿时长
63 days
期刊介绍: NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.
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