Fiammetta Pagano, Nicolaus Kratochwil, Carsten Lowis, Woon-Seng Choong, Marco Paganoni, Marco Pizzichemi, Joshua W Cates, Etiennette Auffray
{"title":"通过双面读取提高异质结构的计时性能。","authors":"Fiammetta Pagano, Nicolaus Kratochwil, Carsten Lowis, Woon-Seng Choong, Marco Paganoni, Marco Pizzichemi, Joshua W Cates, Etiennette Auffray","doi":"10.1088/1361-6560/ad7fc8","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective.</i>Heterostructured scintillators offer a promising solution to balance the sensitivity and timing in TOF-PET detectors. These scintillators utilize alternating layers of materials with complementary properties to optimize performance. However, the layering compromises time resolution due to light transport issues. This study explores double-sided readout-enabling improved light collection and Depth-of-Interaction (DOI) information retrieval-to mitigate this effect and enhance the timing capabilities of heterostructures.<i>Approach.</i>The time resolution and DOI performances of 3 × 3 × 20 mm<sup>3</sup>BGO&EJ232 heterostructures were assessed in a single and double-sided readout (SSR and DSR, respectively) configuration using high-frequency electronics.<i>Main results.</i>Selective analysis of photopeak events yielded a DOI resolution of 6.4 ± 0.04 mm. Notably, the Coincidence Time Resolution (CTR) improved from 262 ± 8 ps (SSR) to 174 ± 6 ps (DSR) when measured in coincidence with a fast reference detector. Additionally, symmetrical configuration of two identical heterostructures in coincidence was tested, yielding in DSR a CTR of 254 ± 8 ps for all photopeak events and 107 ± 5 ps for the fastest events.<i>Significance.</i>By using high-frequency double-sided readout, we could measure DOI resolution and improve the time resolution of heterostructures of up to 40%. The DOI information resulted intrinsically captured in the average between the timestamps of the two SiPMs, without requiring any further correction.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancing timing performance of heterostructures with double-sided readout.\",\"authors\":\"Fiammetta Pagano, Nicolaus Kratochwil, Carsten Lowis, Woon-Seng Choong, Marco Paganoni, Marco Pizzichemi, Joshua W Cates, Etiennette Auffray\",\"doi\":\"10.1088/1361-6560/ad7fc8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective.</i>Heterostructured scintillators offer a promising solution to balance the sensitivity and timing in TOF-PET detectors. These scintillators utilize alternating layers of materials with complementary properties to optimize performance. However, the layering compromises time resolution due to light transport issues. This study explores double-sided readout-enabling improved light collection and Depth-of-Interaction (DOI) information retrieval-to mitigate this effect and enhance the timing capabilities of heterostructures.<i>Approach.</i>The time resolution and DOI performances of 3 × 3 × 20 mm<sup>3</sup>BGO&EJ232 heterostructures were assessed in a single and double-sided readout (SSR and DSR, respectively) configuration using high-frequency electronics.<i>Main results.</i>Selective analysis of photopeak events yielded a DOI resolution of 6.4 ± 0.04 mm. Notably, the Coincidence Time Resolution (CTR) improved from 262 ± 8 ps (SSR) to 174 ± 6 ps (DSR) when measured in coincidence with a fast reference detector. Additionally, symmetrical configuration of two identical heterostructures in coincidence was tested, yielding in DSR a CTR of 254 ± 8 ps for all photopeak events and 107 ± 5 ps for the fastest events.<i>Significance.</i>By using high-frequency double-sided readout, we could measure DOI resolution and improve the time resolution of heterostructures of up to 40%. The DOI information resulted intrinsically captured in the average between the timestamps of the two SiPMs, without requiring any further correction.</p>\",\"PeriodicalId\":20185,\"journal\":{\"name\":\"Physics in medicine and biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics in medicine and biology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6560/ad7fc8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/ad7fc8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Enhancing timing performance of heterostructures with double-sided readout.
Objective.Heterostructured scintillators offer a promising solution to balance the sensitivity and timing in TOF-PET detectors. These scintillators utilize alternating layers of materials with complementary properties to optimize performance. However, the layering compromises time resolution due to light transport issues. This study explores double-sided readout-enabling improved light collection and Depth-of-Interaction (DOI) information retrieval-to mitigate this effect and enhance the timing capabilities of heterostructures.Approach.The time resolution and DOI performances of 3 × 3 × 20 mm3BGO&EJ232 heterostructures were assessed in a single and double-sided readout (SSR and DSR, respectively) configuration using high-frequency electronics.Main results.Selective analysis of photopeak events yielded a DOI resolution of 6.4 ± 0.04 mm. Notably, the Coincidence Time Resolution (CTR) improved from 262 ± 8 ps (SSR) to 174 ± 6 ps (DSR) when measured in coincidence with a fast reference detector. Additionally, symmetrical configuration of two identical heterostructures in coincidence was tested, yielding in DSR a CTR of 254 ± 8 ps for all photopeak events and 107 ± 5 ps for the fastest events.Significance.By using high-frequency double-sided readout, we could measure DOI resolution and improve the time resolution of heterostructures of up to 40%. The DOI information resulted intrinsically captured in the average between the timestamps of the two SiPMs, without requiring any further correction.
期刊介绍:
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry